Endothelial cells (ECs) play a key role to maintain the functionality of blood vessels. Altered EC permeability causes severe impairment in vessel stability and is a hallmark of pathologies such as cancer and thrombosis. Integrating label-free quantitative proteomics data into genome-wide metabolic modeling, we built up a model that predicts the metabolic… (More)
During recent years, there has been increasing awareness of the importance of adopting a holistic view of biodiversity, including agricultural biodiversity, conservation for sustainable utilization and development. These principles have been underlined in the Convention on Biological Diversity and the European efficiency resources towards 2050. Thus… (More)
The original version of this Article contained typographical errors in the Abstract. In the HTML version of the published Article " Lower doses (1–10 mm result ineffective " now reads: " Lower doses (1–10 μ M) result ineffective " In the PDF version of the Article " Lower doses (1–10 μ m result ineffective " now reads: " Lower doses (1–10 μ M) result… (More)
Purinergic signaling is involved in inflammation and cancer. Extracellular ATP accumulates in tumor interstitium, reaching hundreds micromolar concentrations, but its functional role on tumor vasculature and endothelium is unknown. Here we show that high ATP doses (>20 μM) strongly inhibit migration of endothelial cells from human breast carcinoma (BTEC),… (More)
We regret that the table part of Fig. 3 was missed in the online publication. The correct figure is given below.
FAO maintains endothelial permeability 3 Abbreviations: EC endothelial cell FAO fatty acid oxidation TCAc tricarboxylic acid cycle FA fatty acid iMAT integrative metabolic analysis tool GSMM genome-scale metabolic network model SILAC stable-isotope labeling with amino acids in cell culture HUVEC human umbilical vein endothelial cells ECM extracellular… (More)