Daniele Armiento

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Five cases of persistent polyclonal B-cell lymphocytosis (PPBL) with progressive splenomegaly are reported; three were splenectomized. BCL2/IGH rearrangements were found in three cases; HLA-DRB1*07 in all. Bone marrow (BM) trephines showed a moderate lymphoid infiltrate with intrasinusoidal distribution resembling a splenic marginal-zone lymphoma. Splenic(More)
on immunodeficiency: molecular defects in common variable immunodefi-ciency. Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immuno-deficiency: clinical and immunologic outcomes in heterozyogotes. In patients with chronic lymphocytic leukemia (CLL), a family history of hematologic malignancies is(More)
Sickle cell anemia (SCA) remains associated with high risks of morbidity and early death. Allogeneic hematopoietic SCT (HSCT) is the only curative treatment for SCA. We report our experience with transplantation in a group of patients with the non-Black African variant and the Black African variant of SCA. This study included 40 consecutive SCA patients (13(More)
Bone marrow transplantation (BMT) performance can be limited by a lack of ideal donors, and the role of alternative donor hematopoietic cell transplantation in thalassemia is not well established. Here we used a new treatment protocol (Pc 26.1) in 16 thalassemia patients to perform BMT using phenotypically HLA-identical or 1-antigen-mismatched relatives(More)
A comprehensive panel of clinical-biological parameters was prospectively evaluated at presentation in 112 patients with chronic lymphocytic leukemia (<65 years), to predict the risk of progression in early stage disease. Eighty-one percent were in Binet stage A, 19% in stages B/C. Treatment-free survival was evaluated as the time from diagnosis to first(More)
BACKGROUND AND PURPOSE Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for sickle cell anemia (SCA). We report our experience with transplantation in children with the Black African variant of SCA and the effects of transplant on erythroid compartment in bone marrow (BM). PATIENTS AND METHODS Twenty-seven(More)
Photon Astronomy ruled the last four centuries while wider photon band ruled last century of discovery. Present decade may see the rise and competition of UHECR and UHE Neutrino Astronomy. Tau Neutrino may win and be the first flavor revealed. It could soon rise at horizons in AUGER at EeV energies, if nucleons are the main UHECR currier. If on the contrary(More)