Daniela Valdez-Jasso

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Right ventricular (RV) failure in response to pulmonary hypertension (PH) is a severe disease that remains poorly understood. PH-induced pressure overload leads to changes in the RV free wall (RVFW) that eventually results in RV failure. While the development of computational models can benefit our understanding of the onset and progression of PH-induced(More)
In this paper, we analyze how elastic and viscoelastic properties differ across seven locations along the large arteries in 11 sheep. We employ a two-parameter elastic model and a four-parameter Kelvin viscoelastic model to analyze experimental measurements of vessel diameter and blood pressure obtained in vitro at conditions mimicking in vivo dynamics.(More)
The mechanics of the arterial wall is complex, due to its material structure and load conditions, which influence the hemodynamic properties as well as the growth and remodeling process of the cardiovascular system. Arterial remodeling can be found both locally and globally. Local remodeling is typically a result of disease, while global remodeling can be(More)
This paper compares two models predicting elastic and viscoelastic properties of large arteries. Models compared include a Kelvin (standard linear) model and an extended 2-term exponential linear viscoelastic model. Models were validated against in-vitro data from the ovine thoracic descending aorta and the carotid artery. Measurements of blood pressure(More)
A better understanding of the biomechanical properties of the arterial wall provides important insight into arterial vascular biology under normal (healthy) and pathological conditions. This insight has potential to improve tracking of disease progression and to aid in vascular graft design and implementation. In this study, we use linear and nonlinear(More)
Although right-ventricular function is an important determinant of cardio-pulmonary performance in health and disease, right ventricular myocardium mechanical behaviour has received relatively little attention. We present a novel experimental method for quantifying the mechanical behaviour of transmurally intact, viable right-ventricular myocardium. Seven(More)
BACKGROUND Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide phosphoribosyltransferase (NAMPT) is a cytozyme that regulates intracellular nicotinamide adenine dinucleotide levels and cellular redox state, regulates histone deacetylases, promotes cell proliferation, and(More)
INTRODUCTION Tissue engineering offers the possibility of developing a biological substitute material in vitro with the inherent properties required in vivo. However, the inadequate performance in vascular replacement of small diameter vascular grafts (VG) reduces considerably the current alternatives in this field. In this study, a bilayered tubular VG was(More)
INTRODUCTION Generation of a complete map of arterial wall mechanical properties can improve treatment of cardiovascular diseases via contributions to design of patient specific vascular substitutes used to alleviate athero-sclerosis and stenoses, which are predominant in arterial pathways (i.e., abdominal aorta, carotids, or femoral arteries). Clinically(More)