Daniela Mele

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A prospective study was designed to investigate the effects of recombinant human follicle-stimulating hormone (rhFSH) on seminal anti-Müllerian hormone (AMH) levels in men with idiopathic oligoasthenoteratozoospermia (iOAT), researching possible relationships between the seminal AMH behavior and the response to the treatment. Thirty-nine men who were(More)
OBJECTIVE to evaluate the effect of hormone replacement therapy and tibolone on the breast. STUDY DESIGN prospective, controlled, randomized study. SETTING Outpatient Menopause Clinic of the Second University of Naples. PARTICIPANTS forty four women in spontaneous menopause without any risk factor for breast cancer were randomly allocated to three(More)
A prospective randomized controlled study was designed to evaluate the effects of recombinant human follicle-stimulating hormone (rFSH) treatment on sperm DNA fragmentation in men with idiopathic oligoasthenoteratozoospermia (iOAT). One hundred twenty-nine men with sperm count less than 10 × 10(6) spermatozoa/mL and forward motility <25% were included;(More)
In a prospective observational study, 50 healthy patients aged 18-39 years, with regular ovulatory cycle and normal hormone levels, underwent endometrial biopsy in the proliferative and secretory phase of the menstrual cycle for semiquantitative reverse-transcription polymerase chain reaction analysis of mRNA for LGR7, the classic relaxin receptor. LGR7 is(More)
OBJECTIVE To compare the effects of GnRH-agonist/recombinant rFSH versus GnRH-antagonist/recombinant FSH stimulation on follicular fluid levels of soluble intercellular adhesion molecule (sICAM)-1 and vascular cell adhesion molecule-1 (sVCAM-1) during in vitro fertilization (IVF). DESIGN Prospective, randomized study. SETTING University hospital. (More)
OBJECTIVE To evaluate the effectiveness of Gonadotropin-Releasing Hormone analogue when administered preoperatively in hysteroscopic metroplasty. DESIGN Prospective, comparative study. PATIENTS AND MAIN OUTCOME MEASURES Sixty patients undergoing hysteroscopic metroplasty for septate uterus who were randomly allocated to pretreatment with two injections(More)
OBJECTIVE To analyze the reproductive outcome in women undergoing hysteroscopic lysis of intrauterine adhesions, according to their localization and severity. STUDY DESIGN Retrospective study. MATERIALS AND METHODS Fifty-three patients affected by intrauterine adhesions of different degree, subdivided according to localization and morphologic aspect:(More)
BACKGROUND The overall incidence of poor ovarian response in IVF cycles has been reported to be between 9 and 24%. The management of these patients remains a significant challenge in assisted reproduction. The aim of the present study was to evaluate the effect of myo-inositol (MI) on ovarian function in poor responders undergoing ICSI. METHODS The study(More)
BACKGROUND To evaluate the effects on the endometrium of a long term treatment with Tamoxifen in postmenopausal patients, asymptomatic for gynecologic disorders, surgically treated for breast cancer. METHODS SETTING Outpatient menopausal clinic and endoscopic unit. PATIENTS AND INTERVENTIONS 45 patients (Group I) were treated with 20 mg of Tamoxifen(More)
OBJECTIVE To evaluate the effects of hormone replacement therapy (HRT) and of a short-term suspension of HRT on mammographic density. DESIGN Prospective clinical study. SETTING Outpatient menopausal clinic of the Second University of Naples. PATIENT(S) Ninety-seven healthy postmenopausal women. INTERVENTION(S) Thirty-nine menopausal women with(More)