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Bioengineering Dermo-Epidermal Skin Grafts with Blood and Lymphatic Capillaries
Human lymphatic capillaries were engineered in a 3D hydrogel system to improve dermo-epidermal skin grafting. Skin Grafts Need Plumbing, Too To help heal a severe burn or wound, clinicians surgicallyExpand
miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo
ABSTRACT The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses, and promotes cancer metastasis. To address the role microRNAs (miRNAs) play in theExpand
Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin.
Podoplanin is a small transmembrane protein required for development and function of the lymphatic vascular system. To investigate the effects of interfering with its function, we produced an FcExpand
A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitroExpand
Species-specific Inhibition of APOBEC3C by the Prototype Foamy Virus Protein Bet*
The APOBEC3 cytidine deaminases are part of the intrinsic defense of cells against retroviruses. Lentiviruses and spumaviruses have evolved essential accessory proteins, Vif and Bet, respectively,Expand
Vif of Feline Immunodeficiency Virus from Domestic Cats Protects against APOBEC3 Restriction Factors from Many Felids
ABSTRACT To get more insight into the role of APOBEC3 (A3) cytidine deaminases in the species-specific restriction of feline immunodeficiency virus (FIV) of the domestic cat, we tested the A3Expand
Activation of the epidermal growth factor receptor promotes lymphangiogenesis in the skin.
BACKGROUND The lymphatic vascular system regulates tissue fluid homeostasis and plays important roles in immune surveillance, inflammation and cancer metastasis. However, the molecular mechanismsExpand
Restriction of Equine Infectious Anemia Virus by Equine APOBEC3 Cytidine Deaminases
ABSTRACT The mammalian APOBEC3 (A3) proteins comprise a multigene family of cytidine deaminases that act as potent inhibitors of retroviruses and retrotransposons. The A3 locus on the chromosome 28Expand
APOBEC4 Enhances the Replication of HIV-1
APOBEC4 (A4) is a member of the AID/APOBEC family of cytidine deaminases. In this study we found a high mRNA expression of A4 in human testis. In contrast, there were only low levels of A4 mRNAExpand
Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering.
The effect of the production factors yielding a functional dermal substitute was investigated by means of monotonic and cyclic uniaxial tensile tests, as well as electron microscopy visualizations.Expand