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- Martin Kircher, Daniela M. Witten, Preti Jain, Brian J. O'Roak, Gregory M. Cooper, Jay Shendure
- Nature Genetics
- 2014

Current methods for annotating and interpreting human genetic variation tend to exploit a single information type (for example, conservation) and/or are restricted in scope (for example, to missenseâ€¦ (More)

- Daniela M. Witten, Robert Tibshirani, Trevor J. Hastie
- Biostatistics
- 2009

We present a penalized matrix decomposition (PMD), a new framework for computing a rank-K approximation for a matrix. We approximate the matrix X as circumflexX = sigma(k=1)(K) d(k)u(k)v(k)(T), whereâ€¦ (More)

- Patrick Danaher, Pei Xin Wang, Daniela M. Witten
- Journal of the Royal Statistical Society. Seriesâ€¦
- 2014

We consider the problem of estimating multiple related Gaussian graphical models from a high-dimensional data set with observations belonging to distinct classes. We propose the joint graphicalâ€¦ (More)

- Daniela M. Witten, Robert Tibshirani
- Statistical applications in genetics andâ€¦
- 2009

In recent work, several authors have introduced methods for sparse canonical correlation analysis (sparse CCA). Suppose that two sets of measurements are available on the same set of observations.â€¦ (More)

- Daniela M. Witten, Robert Tibshirani
- Journal of the American Statistical Association
- 2010

We consider the problem of clustering observations using a potentially large set of features. One might expect that the true underlying clusters present in the data differ only with respect to aâ€¦ (More)

- Daniela M. Witten, Robert Tibshirani
- Journal of the Royal Statistical Society. Seriesâ€¦
- 2011

We consider the supervised classification setting, in which the data consist of p features measured on n observations, each of which belongs to one of K classes. Linear discriminant analysis (LDA) isâ€¦ (More)

- Tim C. P. Somervaille, Christina J Matheny, +7 authors Michael L. Cleary
- Cell stem cell
- 2009

The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of humanâ€¦ (More)

- Jun Z. Li, Daniela M. Witten, Iain M. Johnstone, Robert Tibshirani
- Biostatistics
- 2012

We discuss the identification of genes that are associated with an outcome in RNA sequencing and other sequence-based comparative genomic experiments. RNA-sequencing data take the form of counts, soâ€¦ (More)

We consider the graphical lasso formulation for estimating a Gaussian graphical model in the high-dimensional setting. This approach entails estimating the inverse covariance matrix under aâ€¦ (More)

- Karthik Mohan, Palma London, Maryam Fazel, Daniela M. Witten, Su-In Lee
- Journal of Machine Learning Research
- 2014

We consider the problem of estimating high-dimensional Gaussian graphical models corresponding to a single set of variables under several distinct conditions. This problem is motivated by the task ofâ€¦ (More)