Daniela M Ruf

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A fundamental limitation in devising new therapeutic strategies for killing cancer cells with DNA damaging agents is the need to identify synthetic lethal interactions between tumor-specific mutations and components of the DNA damage response (DDR) in vivo. The stress-activated p38 mitogen-activated protein kinase (MAPK)/MAPKAP kinase-2 (MK2) pathway is a(More)
AIMS The primary objective was to assess the proportion of detected and correctly referred patients in German primary care. The secondary objective was to identify patient and practitioner characteristics that predict detection and correct referral. METHODS In this clustered cross-sectional survey in German primary care, 3003 patients were consecutively(More)
INTRODUCTION Although several online continuing medical education (CME) offers exist, the utilization of these by physicians is still low. In this study, we aimed to investigate the attitude towards and use of the Internet and online CME in German general practitioners (GPs) and to identify potential starting points to increase the use of online CME. (More)
AIMS This project investigated different dissemination strategies of an online quality improvement programme for alcohol-related disorders into routine care in South Baden and South Württemberg in Germany. METHODS In a cluster-randomized controlled trial, 112 general practices were randomized into three groups. The first group (n = 43) received access to(More)
BACKGROUND AND OBJECTIVE In recent years, there has been an increasing trend towards the development of e-learning-modules for general medical training and continuing medical education (CME). The majority of these offerings make use of the Internet. The aim of this study was to examine general practitioners' attitude towards and their use of the Internet(More)
BACKGROUND Due to the high prevalence of alcohol related disorders (dependent, harmful and at risk drinking) the improvement of the outpatient treatment situation in this area is of major importance. The aim of this study was to examine the treatment structure and modalities of patients with alcohol related disorders in counseling centers for substance(More)
OBJECTIVE Despite the demographically driven rapid growth of the number of persons with dementia, in Germany a website is lacking that provides evidence based information about the disease, its burden and therapeutic options to family and professional carers as well as physicians. A website was developed with the objective to give free access to evidence(More)
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