Daniela Grabher

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Pachyonychia congenita (PC), a rare autosomal-dominant keratin disorder caused by mutations in keratin genes KRT6A/B, KRT16 or KRT17, is characterized by painful plantar keratoderma and hypertrophic nail dystrophy. Loss-of-function mutations in the filaggrin (FLG) gene underlie the most prevalent skin disorder of cornification, ichthyosis vulgaris (IV),(More)
HINTERGRUND: In kürzlich publizierten Studien konnte ein Zusammenhang zwischen Funktionsverlust-Mutationen im Filaggringen (FLG) mit Ichthyosis vulgaris und Neurodermitis (AE) gezeigt werden. Die bisher berichteten Prävalenzen von FLG Mutationen und deren Relation zu atopischen Erkrankungen könnte jedoch durch Fall Selektion verzerrt werden. Daher war es(More)
CYTIP (cytohesin interacting protein) is an intracellular molecule induced in dendritic cells during maturation. CYTIP modulates the binding intensity of the adhesion molecule LFA-1. If dendritic cells are silenced for CYTIP they keep longer contacts with T-cells resulting in a lower T cell stimulation. We identified Suppressor of cytokine signaling-1(More)
The B lymphocyte adaptor molecule of 32 kDa (Bam32) is strongly induced during the maturation of dendritic cells (DC). Most known functions of Bam32 are related to the signaling of the B cell receptor for Ag. Because DC do not express receptors specific for Ags, we aim at characterizing the role of Bam32 in human monocyte-derived DC in this study. Our(More)
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