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In this paper, we describe a hidden two-compartment stochastic process used to model the kinetics of feline hematopoietic stem cells (HSCs) in continuous time. Because of the experimental design and data collection scheme, the inferential task presents numerous challenges. While the hematopoietic process evolves in continuous time, the observations are(More)
BACKGROUND Panic disorder is a prevalent, often disabling condition among patients in the primary care setting. Although numerous studies have assessed the effectiveness of treatments for depression in primary care, few such studies have been conducted for panic disorder. OBJECTIVE To implement and test the effectiveness of a combined pharmacotherapy and(More)
We used stochastic modeling and computer simulation to study the replication, apoptosis, and differentiation of murine hemopoietic stem cells (HSCs) in vivo. This approach allows description of the behavior of an unobserved population (ie, HSCs) on the basis of the behavior of observed progeny cells (ie, granulocytes and lymphocytes). The results of(More)
BACKGROUND: New tools are needed to examine physical activity and the contexts in which it occurs. Community parks contribute to physical activity, but measuring activity and associated variables in them is challenging because area contexts change and the numbers and characteristics of users are highly variable. METHODS: We developed SOPARC (System for(More)
BACKGROUND Many assume that improving the quality and the perceived safety of facilities in parks and recreation centers is critical to attracting more users and increasing population physical activity. There are few studies in which these assumptions have been tested. PURPOSE This study aims to assess the impact of park improvements on park use and(More)
T he U.S. prison population declined for the third consecutive year, falling to an estimated 1,571,013 prisoners at yearend 2012 (figure 1). This was down 27,770 prisoners (1.7%) from yearend 2011. California had the greatest population decline, with 15,035 fewer prisoners than in 2011 in part due to the state's Public Safety Realignment policy. In 2012,(More)
OBJECTIVE To examine a large sample of patients with anxiety and the association between types of complementary and alternative treatments that were used, demographic variables, diagnostic categories, and treatment outcomes. METHOD Cross-sectional and longitudinal survey during the Coordinated Anxiety Learning and Management (CALM) study that assessed(More)
BACKGROUND Despite a marked increase in the number of persons seeking help for anxiety disorders, the care provided may not be evidence based, especially when delivered by nonspecialists. Since anxiety disorders are most often treated in primary care, quality improvement interventions, such as the Coordinated Anxiety Learning and Management (CALM)(More)
CONTEXT Anxiety disorders commonly present in primary care, where evidence-based mental health treatments often are unavailable or suboptimally delivered. OBJECTIVE To compare evidence-based treatment for anxiety disorders with usual care (UC) in primary care for principal and comorbid generalized anxiety disorder (GAD), panic disorder (PD), social(More)
BACKGROUND Randomized clinical trials indicate a benefit from combining medications with cognitive behavioral therapy (CBT) relative to medication alone for panic disorder. Using an as-treated analysis, we evaluated whether the addition of CBT enhanced outcomes for panic disorder relative to medications alone in the primary-care setting. METHOD(More)