Daniela Endt

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Genetic defects in breast cancer (BC) susceptibility genes, most importantly BRCA1 and BRCA2, account for ~40% of hereditary BC and ovarian cancer (OC). Little is known about the contribution of constitutive (soma-wide) epimutations to the remaining cases. We developed bisulfite pyrosequencing assays to screen >600 affected BRCA1/BRCA2 mutation-negative(More)
Neoplasia, ageing, and genetic instability due to defective caretaker genes * Sir, In all human populations, cancer prevalence and ge-nomic instability increase as a function of age, suggesting that loss of genetic homeostasis contributes to car-cinogenesis. Loss of genetic homeostasis is reflected by the accumulation of chromosome damage and DNA(More)
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