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RAD51C was defined by Meindl et al. in 2010 as a high-risk gene involved in hereditary breast and ovarian cancers. Although this role seems to be clear, nowadays there is controversy about the indication of including the gene in routine clinical genetic testing, due to the lower prevalence or the absence of mutations found in subsequent studies. Here, we(More)
Genetic defects in breast cancer (BC) susceptibility genes, most importantly BRCA1 and BRCA2, account for ~40% of hereditary BC and ovarian cancer (OC). Little is known about the contribution of constitutive (soma-wide) epimutations to the remaining cases. We developed bisulfite pyrosequencing assays to screen >600 affected BRCA1/BRCA2 mutation-negative(More)
Neoplasia, ageing, and genetic instability due to defective caretaker genes * Sir, In all human populations, cancer prevalence and ge-nomic instability increase as a function of age, suggesting that loss of genetic homeostasis contributes to car-cinogenesis. Loss of genetic homeostasis is reflected by the accumulation of chromosome damage and DNA(More)
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