Daniela Dorner

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In Drosophila, distinct mechanisms orient asymmetric cell division along the apical-basal axis in neuroblasts and along the anterior-posterior axis in sensory organ precursor (SOP) cells. Here, we show that heterotrimeric G proteins are essential for asymmetric cell division in both cell types. The G protein subunit G(alpha)i localizes apically in(More)
Lamina-associated polypeptide (LAP) 2alpha is a nonmembrane-bound LAP2 isoform that forms complexes with nucleoplasmic A-type lamins. In this study, we show that the overexpression of LAP2alpha in fibroblasts reduced proliferation and delayed entry into the cell cycle from a G0 arrest. In contrast, stable down-regulation of LAP2alpha by RNA interference(More)
PURPOSE A prospective comparative study of a subset of 10 consecutive patients was performed, to describe the effects of an air-inflated rectal balloon tube that has been used for prostate immobilization in 360 patients since 1994. In particular, influences on prostate motion, rectum filling variations, and dose-volume histograms (DVHs) of the rectum during(More)
Lamina-associated polypeptide (LAP) 2α is a chromatin-associated protein that binds A-type lamins. Mutations in both LAP2α and A-type lamins are linked to human diseases called laminopathies, but the molecular mechanisms are poorly understood. The A-type lamin–LAP2α complex interacts with and regulates retinoblastoma protein (pRb), but the significance of(More)
Lamins are major structural components of the nuclear envelope in multicellular eukaryotes. Particularly A-type lamins are also located in the nucleoplasm, likely involving a specific binding partner, lamina-associated polypeptide 2alpha (LAP2alpha). LAP2alpha-lamins A/C complexes in the nucleoplasm have been implicated in the regulation of gene expression(More)
Lamina-associated polypeptide 2alpha (LAP2alpha) is a nuclear protein dynamically associating with chromatin during the cell cycle. In addition, LAP2alpha interacts with A-type lamins and retinoblastoma protein and regulates cell cycle progression via the E2F-Rb pathway. Using yeast two-hybrid analysis and three independent in vitro binding assays we(More)
The MAGIC telescope has observed very-high energy gamma-ray emission from the BL Lac object PG 1553+113 in 2005 and 2006 at an overall significance is 8.8σ . The light curve shows no significant flux variations on a daily timescale. The flux level during 2005 was, however, significantly higher as compared to 2006. The differential energy spectrum between(More)
Very high energy gamma ray emission from the active galactic nucleus PG 1553+113 was observed during 2005 and 2006 by the MAGIC collaboration, for a total observation time of 18.8 hours. Here we present the results of follow up observations: more than 20 hours of good quality data collected by the MAGIC Telescope during the 2007 and 2008 campaigns. The(More)
In this note we discuss preliminary studies concerning a large-diameter gamma-ray telescope, to be part of an array of telescopes installed at the existing observation site on the Canary island of La Palma. One of the telescopes in the array will be MAGIC, presently the largest existing gamma ray telescope and the most performant world wide at low energy. A(More)
Low-dose hyperradiosensitivity (HRS), i.e., a relatively higher efficacy of doses ≤ 0.5 Gy compared to doses > 1 Gy, has been shown in a number of tumor cell lines in vitro. Therefore ultrafractionated irradiation, i.e., application of very low doses per fraction, has been proposed to improve the effects of radiotherapy. The present study investigates(More)