Daniela Breda

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To penetrate susceptible cells, HIV-1 sequentially interacts with two highly conserved cellular receptors, CD4 and a chemokine receptor like CCR5 or CXCR4. Monoclonal antibodies (MAbs) directed against such receptors are currently under clinical investigation as potential preventive or therapeutic agents. We immunized Balb/c mice with molecular complexes of(More)
We have recently introduced a silicon substrate for high-sensitivity microarrays, coated with a functional polymer named copoly(DMA-NAS-MAPS). The silicon dioxide thickness has been optimized to produce a fluorescence intensification due to the optical constructive interference between the incident and reflected lights of the fluorescent radiation. The(More)
The homeostasis of the immune function is severely impaired by HIV exposure, not only as an effect of the infection but also as a consequence of interactions of viral proteins with key elements of the immune system. In this context, in HIV infected individuals autoimmune responses to membrane CD4, the HIV receptor, are generally considered involved in the(More)
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