Daniela Besozzi

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Acknowledgments I am very grateful to all the people I had the privilege to work with, in par-Above all, I would like to thank my advisor Giancarlo Mauri, for his constant interest, encouragement and help. It is a pleasure to take this occasion to thank all the scientists I have met and been in contact with. In particular, my warmest thanks and indebtedness(More)
In the yeast Saccharomyces cerevisiae, the Ras/cAMP/PKA pathway is involved in the regulation of metabolism and cell cycle progression. The pathway is tightly regulated by several control mechanisms, as the feedback cycle ruled by the activity of phosphodiesterase. Here, we present a discrete mathematical model for the Ras/cAMP/PKA pathway that considers(More)
We introduce dynamical probabilistic P systems, a variant where probabilities associated to the rules change during the evolution of the system, as a new approach to the analysis and simulation of the behavior of complex systems. We define the notions for the analysis of the dynamics and we show some applications for the investigation of the properties of(More)
Despite the intense research focused on the investigation of the functioning settings of Particle Swarm Optimization, the particles initialization functions - determining the initial positions in the search space - are generally ignored, especially in the case of real-world applications. As a matter of fact, almost all works exploit uniform distributions to(More)