Daniela Aust

Sort by:

Whole genomes redefine the mutational landscape of pancreatic cancer

Nicola Waddell, Marina Pajic, +86 authors Sean M. Grimmond
Nature
2015

Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal… (More)

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

Susann Weissmueller, Eusebio Manchado, +15 authors Scott W Lowe
Cell
2014

Missense mutations in the p53 tumor suppressor inactivate its antiproliferative properties but can also promote metastasis through a gain-of-function activity. We show that sustained expression of… (More)

Highlights of the EORTC St. Gallen International Expert Consensus on the primary therapy of gastric, gastroesophageal and oesophageal cancer - differential treatment strategies for subtypes of early…

Manfred Paul Lutz, John R Zalcberg, +24 authors Florian Otto
European journal of cancer
2012

The 1st St. Gallen EORTC Gastrointestinal Cancer Conference 2012 Expert Panel clearly differentiated treatment and staging recommendations for the various gastroesophageal cancers. For locally… (More)

Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes

Christof Winter, Glen Kristiansen, +18 authors Robert Grützmann
PLoS Computational Biology
2012

Predicting the clinical outcome of cancer patients based on the expression of marker genes in their tumors has received increasing interest in the past decade. Accurate predictors of outcome and… (More)

Klinisch-experimentelle Untersuchungen zur Entstehung der Porphyrien

Hellmut Ippen, Daniela Aust, Günther Görz
Archiv für dermatologische Forschung
2004

The influence of estrogens, gestagens and androgens onto the porphyrin metabolism was studied over some months in adult male rats either normal or with a slight liver damage by hexachlorobenzene… (More)

Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer.

Yvonne Mueller-Koch, Harald Vogelsang, +13 authors Elke Holinski-Feder
Gut
2005

BACKGROUND Hereditary non-polyposis colorectal cancer (HNPCC) is clinically defined by familial clustering of colorectal cancer and other associated tumours. METHODS By thorough molecular and… (More)

WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer.

Heidi Griesmann, Stefanie Ripka, +7 authors Patrick Michl
Neoplasia
2013

INTRODUCTION WNT5A belongs to the Wnt family of secreted signaling molecules. Using transcriptional profiling, we previously identified WNT5A as target of the antiapoptotic transcription factor CUX1… (More)

Five primary human pancreatic adenocarcinoma cell lines established by the outgrowth method.

Felix Rückert, Daniela Aust, +8 authors Christian Pilarsky
The Journal of surgical research
2012

BACKGROUND Pancreatic ductal adenocarcinoma is an aggressive tumor; treatment remains a challenge because of the lack of effective therapeutic strategies. Basic research in this field is dependent on… (More)

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

Roland Rad, L. Kazemi Rad, +42 authors Allan Bradley
Nature Genetics
2015

Here we describe a conditional piggyBac transposition system in mice and report the discovery of large sets of new cancer genes through a pancreatic insertional mutagenesis screen. We identify Foxp1… (More)

Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.

Marie-Claude Gingras, Kyle R. Covington, +42 authors Richard A. Gibbs
Cell reports
2016

The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors. To evaluate the molecular features of these tumors,… (More)

Filter Results:

Publication Year

Publication Type

Co-author

Journals and Conferences