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Targeting specific molecular alterations in glioblastoma (GBM) might more effectively kill tumor cells and increase survival. Vandetanib inhibits epidermal growth factor receptor and vascular endothelial growth factor receptor 2. Sirolimus inhibits mammalian target of rapamycin (mTOR), a member the phosphoinositide 3-Kinase signaling pathway. We sought to(More)
Appendicitis is the most common indication for emergency pediatric surgery and its most significant complication is perforation. Perforated appendicitis (PA) may be managed conservatively, whereas non-perforated appendicitis (NP) is managed surgically. Recent studies have shown that ultrasound (US) is effective for differentiating between PA and NP, and(More)
Treatment duration as well as time spent on patient positioning imposes limitations on therapeutic use of MR-guided High Intensity Focused Ultrasound (MR-HIFU). Reduction of overall treatment time is especially important in potential pediatric applications and in other cases where general anesthesia must be used, due to the risks associated with prolonged(More)
Magnetic resonance-guided high intensity focused ultra-sound (MR-HIFU) ablation provides a precise, non-inva-sive treatment for lesions in adults. In children, MR-HIFU's potential remains largely unexplored, though its non-invasive and non-ionizing nature holds promise. Yet, pediatric patients pose challenges affecting treatment: young children require(More)
Background/introduction MR-guided high-intensity focused ultrasound (MR-HIFU) treatments may cause skin heating in the vicinity of the treatment site. Current MR thermometry methods do not provide reliable measurements of skin temperature either during the sonication or during the cool-down periods between sonications. These technical challenges require(More)
It was expected that recombinant Aspergillus niger glucose oxidase could be expressed in Trichoderma reesei with stable activity. T. reesei CBHI promoter--CBHI ss. gene--A. niger glucose oxidase gene--T. reesei CBHI terminator--A. nidulans gpd promoter--E. coli Hygromycin B phosphotransferase gene--A. nidulans trpC terminator--pUC19 (pCBHGOD) vector was(More)
Ball-balancing robots (BBRs) are endowed with rich dynamics. When properly designed and stabilized via feedback to eliminate jitter, and intuitively coordinated with a well-designed smartphone interface, BBRs exhibit a uniquely fluid and organic motion. Unlike mobile inverted pendulums (MIPs, akin to unmanned Segways), BBRs stabilize both fore/aft and(More)
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