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We present a joint probability model for statistical machine translation, which automatically learns word and phrase equivalents from bilingual corpora. Translations produced with parameters estimated using the joint model are more accurate than translations produced using IBM Model 4. 1 Motivation Most of the noisy-channel-based models used in statistical(More)
To systematically investigate the impact of immune stimulation upon regulatory variant activity, we exposed primary monocytes from 432 healthy Europeans to interferon-γ (IFN-γ) or differing durations of lipopolysaccharide and mapped expression quantitative trait loci (eQTLs). More than half of cis-eQTLs identified, involving hundreds of genes and associated(More)
Server energy proportionality has been improving over the past several years. Many components in a system, such as CPU, memory and disk, have been achieving good energy proportionality behavior. Using a wide range of server power data from the published SPEC power data we show that the overall system energy proportionality has reached 80%. We present two(More)
The unique DNA-binding properties of distinct NF-κB dimers influence the selective regulation of NF-κB target genes. To more thoroughly investigate these dimer-specific differences, we combined protein-binding microarrays and surface plasmon resonance to evaluate DNA sites recognized by eight different NF-κB dimers. We observed three distinct(More)
With the widespread adoption of GPGPUs in varied application domains, new opportunities open up to improve GPGPU energy efficiency. Due to inherent application-level inefficiencies, GPGPU execution units experience significant idle time. In this work we propose to power gate idle execution units to eliminate leakage power, which is becoming a significant(More)
Genetic studies have provided ample evidence of the influence of non-coding DNA polymorphisms on trait variance, particularly those occurring within transcription factor binding sites. Protein binding microarrays and other platforms that can map these sites with great precision have enhanced our understanding of how a single nucleotide polymorphism can(More)
OBJECTIVE To investigate the relationship of glutamate and glutamate transporter expression in human gliomas and surrounding peritumoral brain to the presence of tumor-associated seizures (TAS). METHODS We studied a retrospective (group 1: 190 patients) and then a prospective (group 2: 98 patients) cohort of patients who underwent a craniotomy for a(More)
Endoplasmic reticulum-mitochondrial contacts, known as mitochondria-associated membranes, regulate important cellular functions including calcium signaling, bioenergetics, and apoptosis. Human cytomegalovirus is a medically important herpesvirus whose growth increases energy demand and depends upon continued cell survival. To gain insight into how human(More)
Human cytomegalovirus (HCMV) UL37 proteins traffic sequentially from the endoplasmic reticulum (ER) to the mitochondria. In transiently transfected cells, UL37 proteins traffic into the mitochondrion-associated membranes (MAM), the site of contact between the ER and mitochondria. In HCMV-infected cells, the predominant UL37 exon 1 protein, pUL37x1,(More)
Current trends signal an imminent crisis in the simulation of future CMPs (Chip Multiprocessors). Future micro-architectures will offer more and more thread contexts to execute parallel programs, but the execution speed of each thread will not improve at the same pace. CMPs with 10’s or even100’s of cores are envisioned. Simulating these future(More)