Daniel Weiss

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BACKGROUND Hyperglycaemia is associated with increased risk of cardiovascular complications in people with type 2 diabetes. We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes. METHODS ACCORD was a parallel-group, randomised trial done in 77 clinical sites in(More)
Cryptochromes are flavoproteins that act as sensory blue light receptors in insects, plants, fungi, and bacteria. We have investigated a cryptochrome from the green alga Chlamydomonas reinhardtii with sequence homology to animal cryptochromes and (6-4) photolyases. In response to blue and red light exposure, this animal-like cryptochrome (aCRY) alters the(More)
Our research explored factors that impacted the use of wikis as a tool to support the dissemination of knowledge within an enterprise. Although we primarily talked to a population of wiki contributors and readers, we discovered two major factors which contributed to staff's unwillingness to share information on a wiki under certain circumstances. First, we(More)
Gait and balance disturbances typically emerge in advanced Parkinson's disease with generally limited response to dopaminergic medication and subthalamic nucleus deep brain stimulation. Therefore, advanced programming with interleaved pulses was put forward to introduce concomittant nigral stimulation on caudal contacts of a subthalamic lead. Here, we(More)
Mesenteric lymphadenitis (ML) is considered as one of the most common alternative diagnosis in a child with suspected acute appendicitis (AA). In this retrospective study, patients diagnosed with ML (n = 99) were compared in terms of demographic, clinical, and laboratory findings to patients diagnosed with AA (n = 102). This comparison was applied for both(More)
Severe gait disturbances in idiopathic Parkinson’s disease (PD) are observed in up to 80% of all patients in advanced disease stages [1, 2] with an important impact on quality of life [3–5]. While segmental symptoms generally respond well to dopaminergic medication and high-frequent deep brain stimulation of the subthalamic nucleus (STN-DBS), treatment of(More)
Whether patients with genetically defined Parkinson’s disease (PD) may be particularly eligible to benefit from deep brain stimulation of the nucleus subthalamicus (STN-DBS) is currently the subject of debate. We report on a patient with advanced PD due to R793M missense mutation in the LRRK2 gene successfully treated by STN-DBS. Disease onset was at age 42(More)
Lesion segmentation in MRI scans is used for lesion quantification as pertaining to various medical conditions. We propose a novel technique for chronic stroke lesion segmentation based on multiple modalities including T1-weighted and T2-weighted images as well as diffusion tensor-based modalities. The proposed approach is based on a mixture-parametric(More)
Dynamic modulations of large-scale network activity and synchronization are inherent to a broad spectrum of cognitive processes and are disturbed in neuropsychiatric conditions including Parkinson's disease. Here, we set out to address the motor network activity and synchronization in Parkinson's disease and its modulation with subthalamic stimulation. To(More)
We evaluated an integrated social software platform, called Handshake, to determine individuals' usage patterns and characterize Handshake's business value. Our multi-step investigation included conducting 63 in-depth interviews, analyzing log data from 4600+ users, and administering an online survey. We found that both the level and type of participation(More)