Hermann Stefan8
Ingmar Blümcke6
8Hermann Stefan
6Ingmar Blümcke
Learn More
Visual field deficits due to optic radiation injury are a common complication of temporal lobectomy in epilepsy surgery. In this prospective study, diffusion tensor imaging (DTI) based fiber tracking was performed on 48 patients who had temporal lobectomy for pharmaco-resistant epilepsy. Pre- and intra-operative DTI based fiber tracking was used to(More)
In patients with pharmacoresistant focal epilepsy,we demonstrate that magnetoencephalography (MEG) detects spike-locked and spike-independent epileptic high gamma oscillations (HGOs) using combined MEG and invasive electroencephalography (iEEG) from subdural macroelectrodes. Six patients, who underwent presurgical workup for epilepsy surgery with(More)
The hippocampal dentate gyrus maintains its capacity to generate new neurons throughout life. In animal models, hippocampal neurogenesis is increased by cognitive tasks, and experimental ablation of neurogenesis disrupts specific modalities of learning and memory. In humans, the impact of neurogenesis on cognition remains unclear. Here, we assessed the(More)
Mesial temporal sclerosis (MTS) is the most common lesion in chronic, intractable temporal lobe epilepsies (TLE) and characterized by segmental neuronal cell loss in major hippocampal segments. Another histopathological hallmark includes granule cell dispersion (GCD), an architectural disturbance of the dentate gyrus encountered in approximately 50% of(More)
  • Ingmar Blümcke, Iris Kistner, Hans Clusmann, Johannes Schramm, Albert J Becker, Christian E Elger +10 others
  • 2009
The dentate gyrus (DG) plays a pivotal role in the functional and anatomical organization of the hippocampus and is involved in learning and memory formation. However, the impact of structural DG abnormalities, i.e., granule cell dispersion (GCD), for hippocampal seizure susceptibility and its association with distinct lesion patterns in epileptic(More)
We present a web based eLearning system to support software modeling exercises in large-scale software engineering courses. Students get the task to create a domain model based on a given textual specification of an application domain. They have to specify the domain model by a UML class diagram and import it into the eLearning system. The system verifies(More)
Focal cortical dysplasias (FCD) which represent a composite group of cortical malformations are increasingly recognized as morphological substrate for severe therapy-refractory epilepsy in children and young adults. However, presurgical evaluation remains challenging as not all FCD variants can be reliably detected by high-resolution magnetic resonance(More)
BACKGROUND Surgical treatment of brainstem cavernous angioma involving eloquent fiber tracts is one of the most challenging areas of contemporary neurosurgery. Diffusion tensor imaging-based fiber tracking adds essential information for preoperative planning in neurosurgical practice. Integration of the tractography into neuronavigation system makes it(More)
PURPOSE This study aimed to analyze magnetoencephalography (MEG) localizations of epileptic clusters in different cortical regions of the frontal lobe and relate these findings to postoperative outcomes associated with frontal lobe epilepsy (FLE). METHODS Thirty-nine patients from the Epilepsy Center of Erlangen-Nuremberg University with or without(More)
OBJECTIVE The aim of this study was to investigate the correlation of ictal semiology with localization and/or lateralization by magnetoencephalography (MEG). METHODS Seven patients from the Neurology Department of the University Hospital Erlangen who underwent resective surgery for frontal lobe epilepsy (FLE) with an Engel 1a outcome were investigated(More)
  • 1