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Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart
Background— Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac remodeling and chronic… Expand
Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation.
- Brian E Sansbury, S. P. Jones, Daniel W. Riggs, V. Darley-Usmar, B. Hill
- Biology, Medicine
- Chemico-biological interactions
- 30 May 2011
The ability of the cell to generate sufficient energy through oxidative phosphorylation and to maintain healthy pools of mitochondria are critical for survival and maintenance of normal biological… Expand
Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury.
RATIONALE Myocardial ischemia-reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation-derived unsaturated aldehydes. However, the… Expand
Exposure to acrolein by inhalation causes platelet activation.
- S. Sithu, Sushilkumar Srivastava, +7 authors S. D'Souza
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 15 October 2010
Acrolein is a common air pollutant that is present in high concentrations in wood, cotton, and tobacco smoke, automobile exhaust and industrial waste and emissions. Exposure to acrolein containing… Expand
FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise
- Andrew A. Gibb, Lindsey A. McNally, Daniel W. Riggs, D. Conklin, A. Bhatnagar, B. Hill
- Front. Physiol.
- 21 December 2016
Mice are commonly used to examine the mechanisms by which exercise improves cardiometabolic health; however, exercise compliance and adaptations are often strain-dependent or are variable due to… Expand
Acrolein Exposure Is Associated With Increased Cardiovascular Disease Risk
- Natasha DeJarnett, D. Conklin, +20 authors A. Bhatnagar
- Journal of the American Heart Association
- 1 August 2014
Background Acrolein is a reactive aldehyde present in high amounts in coal, wood, paper, and tobacco smoke. It is also generated endogenously by lipid peroxidation and the oxidation of amino acids by… Expand
Comparison of Urinary Biomarkers of Exposure in Humans Using Electronic Cigarettes, Combustible Cigarettes, and Smokeless Tobacco.
- P. Lorkiewicz, Daniel W. Riggs, +6 authors A. Bhatnagar
- Nicotine & tobacco research : official journal of…
- 19 August 2019
Background Cigarette smoking is associated with an increase in cardiovascular disease risk, attributable in part to reactive volatile organic chemicals (VOCs). However, little is known about the… Expand
Defining the Human Envirome: An Omics Approach for Assessing the Environmental Risk of Cardiovascular Disease.
Both genetic and environmental factors contribute to the development of cardiovascular disease, but in comparison with genetics, environmental factors have received less attention. Evaluation of… Expand
Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism.
- Brian E Sansbury, Daniel W. Riggs, Robert E. Brainard, Joshua K. Salabei, S. P. Jones, B. Hill
- Biology, Medicine
- The Biochemical journal
- 15 April 2011
During cardiac remodelling, the heart generates higher levels of reactive species; yet an intermediate 'compensatory' stage of hypertrophy is associated with a greater ability to withstand oxidative… Expand
High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration
Abstract Planarians are outstanding models for studying mechanisms of regeneration; however, there are few methods to measure changes in their metabolism. Examining metabolism in planarians is… Expand