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Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart
Background— Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac remodeling and chronicExpand
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Bioenergetic function in cardiovascular cells: the importance of the reserve capacity and its biological regulation.
The ability of the cell to generate sufficient energy through oxidative phosphorylation and to maintain healthy pools of mitochondria are critical for survival and maintenance of normal biologicalExpand
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Genetic Deficiency of Glutathione S-Transferase P Increases Myocardial Sensitivity to Ischemia-Reperfusion Injury.
RATIONALE Myocardial ischemia-reperfusion (I/R) results in the generation of oxygen-derived free radicals and the accumulation of lipid peroxidation-derived unsaturated aldehydes. However, theExpand
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Exposure to acrolein by inhalation causes platelet activation.
Acrolein is a common air pollutant that is present in high concentrations in wood, cotton, and tobacco smoke, automobile exhaust and industrial waste and emissions. Exposure to acrolein containingExpand
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FVB/NJ Mice Are a Useful Model for Examining Cardiac Adaptations to Treadmill Exercise
Mice are commonly used to examine the mechanisms by which exercise improves cardiometabolic health; however, exercise compliance and adaptations are often strain-dependent or are variable due toExpand
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Acrolein Exposure Is Associated With Increased Cardiovascular Disease Risk
Background Acrolein is a reactive aldehyde present in high amounts in coal, wood, paper, and tobacco smoke. It is also generated endogenously by lipid peroxidation and the oxidation of amino acids byExpand
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Comparison of Urinary Biomarkers of Exposure in Humans Using Electronic Cigarettes, Combustible Cigarettes, and Smokeless Tobacco.
Background Cigarette smoking is associated with an increase in cardiovascular disease risk, attributable in part to reactive volatile organic chemicals (VOCs). However, little is known about theExpand
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Defining the Human Envirome: An Omics Approach for Assessing the Environmental Risk of Cardiovascular Disease.
Both genetic and environmental factors contribute to the development of cardiovascular disease, but in comparison with genetics, environmental factors have received less attention. Evaluation ofExpand
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Responses of hypertrophied myocytes to reactive species: implications for glycolysis and electrophile metabolism.
During cardiac remodelling, the heart generates higher levels of reactive species; yet an intermediate 'compensatory' stage of hypertrophy is associated with a greater ability to withstand oxidativeExpand
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High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration
Abstract Planarians are outstanding models for studying mechanisms of regeneration; however, there are few methods to measure changes in their metabolism. Examining metabolism in planarians isExpand
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