Daniel W. Nebert

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Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.

Peter I. Mackenzie, Karl Walter Bock, +6 authors Daniel W. Nebert
Pharmacogenetics and genomics
2005

Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases, have been identified in the human, mouse and rat genomes and in other mammalian species. This review provides… (More)

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

David R. Nelson, Luc M. H. Koymans, +9 authors Daniel W. Nebert
Pharmacogenetics
1996

We provide here a list of 481 P450 genes and 22 pseudogenes, plus all accession numbers that have been reported as of October 18, 1995. These genes have been described in 85 eukaryote (including… (More)

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

David R. Nelson, Darryl C. Zeldin, Susan M. G. Hoffman, Lois J. Maltais, Hester M. Wain, Daniel W. Nebert
Pharmacogenetics
2004

OBJECTIVES Completion of both the mouse and human genome sequences in the private and public sectors has prompted comparison between the two species at multiple levels. This review summarizes the… (More)

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.

Daniel W. Nebert, Timothy P. Dalton, Allan B. Okey, Frank J. Gonzalez
The Journal of biological chemistry
2004

The mammalian CYP1A1, CYP1A2, and CYP1B1 genes (encoding cytochromes P450 1A1, 1A2, and 1B1, respectively) are regulated by the aromatic hydrocarbon receptor (AHR). The CYP1 enzymes are responsible… (More)

Clinical importance of the cytochromes P450

The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids;… (More)

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

Peter I. Mackenzie, Ida S. Owens, +16 authors Daniel W. Nebert
Pharmacogenetics
1997

This review represents an update of the nomenclature system for the UDP glucuronosyltransferase gene superfamily, which is based on divergent evolution. Since the previous review in 1991, sequences… (More)

Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis.

Daniel W. Nebert, Amy L. Roe, Matthew Z Dieter, Willy A. Solis, Yuhua Yang, Timothy P. Dalton
Biochemical pharmacology
2000

The chronology and history of characterizing the aromatic hydrocarbon [Ah] battery is reviewed. This battery represents the Ah receptor (AHR)-mediated control of at least six, and probably many more,… (More)

Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation.

Shigeyuki Uno, Timothy P. Dalton, +4 authors Daniel W. Nebert
Molecular pharmacology
2004

The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with… (More)

P450 genes: structure, evolution, and regulation.

Daniel W. Nebert, Frank J. Gonzalez
Annual review of biochemistry
1987

The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis

Daniel W. Nebert, Timothy P. Dalton
Nature Reviews Cancer
2006

Some cytochrome P450 (CYP) heme-thiolate enzymes participate in the detoxication and, paradoxically, the formation of reactive intermediates of thousands of chemicals that can damage DNA, as well as… (More)

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