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  • Rajeev S. Bhide, Zhen-wei Cai, +25 authors Joseph Fargnoli
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2006 (First Publication: 1 April 2006)
  • A series of substituted 4-(4-fluoro-1H-indol-5-yloxy)pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of vascular endothelial growth factor receptor-2 kinase is reported. Structure-activityContinue Reading
  • Zhen-wei Cai, Yongzheng Zhang, +21 authors Rajeev S. Bhide
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2008 (First Publication: 1 March 2008)
  • A series of amino acid ester prodrugs of the dual VEGFR-2/FGFR-1 kinase inhibitor 1 (BMS-540215) was prepared in an effort to improve the aqueous solubility and oral bioavailability of the parentContinue Reading
  • Rajeev S. Bhide, Louis John Lombardo, +12 authors Joseph Fargnoli
  • Biology, Medicine
  • Molecular cancer therapeutics
  • 2010 (First Publication: 1 February 2010)
  • Tumor angiogenesis is a complex and tightly regulated network mediated by various proangiogenic factors. The fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) family ofContinue Reading
  • Robert M. Borzilleri, Xiaoping Zheng, +15 authors Rajeev S. Bhide
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2005 (First Publication: 1 June 2005)
  • A series of substituted 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines was identified as potent and selective inhibitors of the tyrosine kinase activity of the growthContinue Reading
  • Kathleen M. Gillooly, Mark A. Pattoli, +19 authors J. Richard Burke
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 2009 (First Publication: 1 November 2009)
  • We have previously shown that inhibitors of IkappaB kinase beta (IKKbeta), including 4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline (BMS-345541), are efficacious against experimentalContinue Reading
  • Robert M. Borzilleri, Rajeev S. Bhide, +14 authors Louis John Lombardo
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2006 (First Publication: 1 June 2006)
  • Substituted 3-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzamides were identified as potent and selective inhibitors of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity.Continue Reading
  • Tai Wai Wong, Francis Y F Lee, +16 authors Chiang Yu
  • Medicine, Biology
  • Clinical cancer research : an official journal of…
  • 2011 (First Publication: 15 June 2011)
  • PURPOSE The extensive involvement of the HER kinases in epithelial cancer suggests that kinase inhibitors targeting this receptor family have the potential for broad spectrum antitumor activity.Continue Reading