Daniel Timofte

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The pancreatic cancer is a disease with exponentially increased incidence, especially over the last decades, being the sixth or even fifth cause of death by cancer in most of the modern societies. Moreover, it is estimated that almost 95% of the patients with this disease are presenting to the doctor in the advanced and unresectable stages. Also, over the(More)
The present paper focuses on solid lipid particles (SLPs), described in the literature as the most effective lipid drug delivery systems that have been introduced in the last decades, as they actually combine the advantages of polymeric particles, hydrophilic/lipophilic emulsions and liposomes. In the current study, we present our most recent advances in(More)
The modern treatment for alcohol dependence is still problematic, in many cases with the costs exceeding benefits. In these conditions a new management approach was developed lately, known as the systemic therapy. In this way, the crystallization and practical transposition of this new treatment approach is represented by the Clubs of Alcoholics in(More)
Obesity has become one of the world’s major health issues due to its endemic progression and associated comorbidities. The International Association for the Study of Obesity reported that approximately 40-50% of men and 25-35% of women in the EU were overweight (defined as a BMI between 25.0 and 29.9 kg/m2), and an additional 15-25% of men and 15-25% of(More)
Pain is a subjective phenomenon, not fully understood, which is manifesting abnormally in most of the disorders. Also, in the case of schizophrenia, a psychiatric disorder marked by gross distortion from reality, disturbances in thinking, feeling and behavior, pain behaves in an unpredictable manner, just like the evolution of this mental disorder. In this(More)
Using the stomach as a substitution after oesophagectomy is the most common method. The stomach brought intra thoracic it seems that maintains or regains its capacity to secrete hydrochloric acid and therefore can develop specific conditions, despite total denervation following bilateral troncular vagotomy. We are presenting the case of a young patient who(More)
AIM To determine the correct therapeutic approach to the different grades of liver trauma. MATERIAL AND METHODS The study is based on a retrospective analysis of treatment outcomes in 56 patients with abdominal trauma admitted over a 9-year period to in the IIIrd Surgical Clinic of the Iasi "Sf. Spiridon" Hospital. It is focused on operative or(More)
Lately, there is increased evidence that besides the very well known angiotensin (Ang) II, other renin-angiotensin system (RAS) peptides, including Ang III, Ang IV or Ang-(1–7), could mediate important effects at the central level. Thus, very few aspects are known about the central actions of Ang-(1-7), while the effects of its administration alone on(More)
Lately the oncological research literature depicted an increased interest towards the pancreatic cancer, especially considering its growing incidence (rapidly becoming the fifth cause of death by cancer in the developed countries), lack of any sustainable markers and/or risk factors and the chilling fact that almost 95% of the patients with this disorder(More)