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Dopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight dopaminergic neurons. Using an automated particle-tracking system for the analysis of C. elegans locomotion, we observed that individual(More)
The modification of behavior in response to experience is crucial for animals to adapt to environmental changes. Although factors such as neuropeptides and hormones are known to function in the switch between alternative behavioral states, the mechanisms by which these factors transduce, store, retrieve, and integrate environmental signals to regulate(More)
Acute food deprivation causes N2 animals to modulate their locomotion differently than well-fed animals upon entering a bacterial lawn. Acutely food-deprived animals exhibit a serotonin-dependent 'enhanced slowing response' upon entering a bacterial lawn while well-fed animals exhibit a dopamine-dependent 'basal slowing response' upon entering a bacterial(More)
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