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Conditional Deletion of the Pten Gene in the Mouse Prostate Induces Prostatic Intraepithelial Neoplasms at Early Ages but a Slow Progression to Prostate Tumors
The PTEN tumor suppressor gene is frequently inactivated in human prostate cancer. Using Osr1 (odd skipped related 1)-Cre mice, we generated a novel conditional Pten knockout mouse strain,Expand
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Deletion of Leucine Zipper Tumor Suppressor 2 (Lzts2) Increases Susceptibility to Tumor Development*
Background: The leucine zipper putative tumor suppressor 2 (LZTS2) has been speculated to be a tumor suppressor for more than a decade. Results: Deletion of Lzts2 increases the susceptibility toExpand
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Conditional Expression of the Androgen Receptor Induces Oncogenic Transformation of the Mouse Prostate*
Background: The androgen signaling pathway mediated through the AR is critical in prostate tumorigenesis. However, the precise role of AR in prostate tumorigenesis still remains largely unknown.Expand
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Androgen Signaling Is a Confounding Factor for β-catenin-mediated Prostate Tumorigenesis
Emerging evidence has demonstrated the critical roles for both androgen and Wnt pathways in prostate tumorigenesis. A recent integrative genomic analysis of human prostate cancers (PCas) has revealedExpand
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Wnt/β‐Catenin‐Responsive Cells in Prostatic Development and Regeneration
The precise role of Wnt/β‐catenin signaling during prostatic development and tumorigenesis is unclear. Axin2 is a direct transcriptional target of β‐catenin. Recent studies have shown thatExpand
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LZTS2 and PTEN collaboratively regulate ß-catenin in prostatic tumorigenesis
The leucine zipper tumor suppressor 2 (LZTS2) was identified as a tumor susceptibility gene within the 10q24.3 chromosomal region, and is approximately 15Mb from the PTEN locus. This regionExpand
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The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development
  • Y. Peng, C. Clark, +6 authors Z. Sun
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 26 September 2011
Background: The LZTS2 is a novel β-catenin-interacting protein, and its role in development and tumorigenesis is unknown. Results: Lzts2 KO mice show severe kidney and urinary tract developmentalExpand
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Conditional Expression of the Androgen Receptor Increases Susceptibility of Bladder Cancer in Mice
Bladder cancer represents a significant human tumor burden, accounting for about 7.7% and 2.4% of all cancer cases in males and females, respectively. While men have a higher risk of developingExpand
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Identification of a Novel Role of ZMIZ2 Protein in Regulating the Activity of the Wnt/β-Catenin Signaling Pathway*
Background: ZMIZ2 is a transcriptional coactivator, but its biological role has not been fully investigated. Results: We demonstrate a promotional role of ZMIZ2 in β-catenin-mediated transcriptionExpand
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Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate
Emerging evidence has shown that the hepatocyte growth factor (HGF) and its receptor, MET proto-oncogene, receptor tyrosine kinase (MET), promote cell proliferation, motility, morphogenesis, andExpand
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