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PURPOSE To determine the feasibility and diagnostic accuracy of high-spatial-resolution myocardial perfusion magnetic resonance (MR) imaging at 3.0 T by using k-space and time (k-t) domain undersampling with sensitivity encoding (SENSE), or k-t SENSE. Data were compared with results of k-t SENSE-accelerated high-spatial-resolution perfusion MR imaging at(More)
BACKGROUND Percutaneous mitral valve repair (MVR) using the MitraClip system has become a valid alternative for patients with severe mitral regurgitation (MR) and high operative risk. OBJECTIVE To identify clinical and periprocedural factors that may have an impact on clinical outcome. DESIGN Multi-centre longitudinal cohort study. SETTING Tertiary(More)
AIMS To evaluate the feasibility and diagnostic performance of high spatial resolution myocardial perfusion cardiac magnetic resonance (perfusion-CMR). METHODS AND RESULTS Fifty-four patients underwent adenosine stress perfusion-CMR. An in-plane spatial resolution of 1.4 × 1.4 mm(2) was achieved by using 5× k-space and time sensitivity encoding (k-t(More)
OBJECTIVE Analyse 2-year outcomes after MitraClip therapy and identify predictors of outcome. METHODS Consecutive patients (n=74) undergoing MitraClip therapy were included in the MitraSWISS registry and followed prospectively. RESULTS A reduction of mitral regurgitation (MR) to ≤ mild was achieved in 32 (43%) patients and to moderate in 31 (42%)(More)
AIMS To assess the feasibility, short-term durability and clinical outcomes of MitraClip® therapy for mitral regurgitation (MR) in patients with end-stage heart failure and a severely reduced left ventricular (LV) ejection fraction. METHODS AND RESULTS We analysed retrospectively collected data from seven European centres. Included in the study were 50(More)
RATIONALE The meta-Analysis of Cell-based CaRdiac study is the first prospectively declared collaborative multinational database, including individual data of patients with ischemic heart disease treated with cell therapy. OBJECTIVE We analyzed the safety and efficacy of intracoronary cell therapy after acute myocardial infarction (AMI), including(More)
OBJECTIVES This study sought to assess outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI) for unprotected left main (LM) disease. BACKGROUND Limited data are available on outcomes in patients with ST-segment elevation myocardial infarction undergoing LM PCI. METHODS Of 9,075(More)
BACKGROUND Percutaneous mitral valve repair with the MitraClip device has emerged as an alternative to surgery for treating severe mitral regurgitation. However, its effects on left ventricular loading conditions and contractility have not been investigated yet. METHODS AND RESULTS Pressure-volume loops were recorded throughout the MitraClip procedure(More)
PURPOSE To assess a late gadolinium enhancement (LGE) single-breath-hold three-dimensional (3D) inversion recovery magnetic resonance (MR) imaging sequence for the quantification of myocardial scar mass and transmurality in comparison with a clinically established two-dimensional (2D) sequence. MATERIALS AND METHODS All patients gave written informed(More)
The X-linked ANG II type 2 receptor (AT2) is supposed to be involved in cardiovascular disorders. Two studies associated the A allele of the AT2 gene polymorphism (PM) 1675 G/A with left ventricular hypertrophy in men and coronary ischemia in women. Because the PM is located in the short intron 1 of the AT2 gene within a sequence motif similar to the splice(More)