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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

• Franziska Bollmann, Julia Art, +18 authors Andrea Pautz
• Nucleic acids research
• 2014

Resveratrol shows beneficial effects in inflammation-based diseases like cancer, cardiovascular and chronic inflammatory diseases. Therefore, the molecular mechanisms of the anti-inflammatory… (More)

Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells

• Daniel Siuda, Ulrich Zechner, +8 authors Huige Li
• Basic Research in Cardiology
• 2012

Nox4 is a member of the NADPH oxidase family, which represents a major source of reactive oxygen species (ROS) in the vascular wall. Nox4-mediated ROS production mainly depends on the expression… (More)

Maternal treatment of spontaneously hypertensive rats with pentaerythritol tetranitrate reduces blood pressure in female offspring.

• Zhixiong Wu, Daniel Siuda, +5 authors Huige Li
• Hypertension
• 2015

Pentaerythritol tetranitrate is devoid of nitrate tolerance and shows no reproductive or developmental toxicity in animal studies. Recently, pentaerythritol tetranitrate has been demonstrated to… (More)

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol.

• Ning Xia, Susanne Strand, +5 authors Huige Li
• Nitric oxide : biology and chemistry
• 2013

Many of the cardiovascular protective effects of resveratrol are attributable to an enhanced production of nitric oxide (NO) by the endothelial NO synthase (eNOS). Resveratrol has been shown to… (More)

Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells.

• Daniel Siuda, Silke Tobias, Alma Rus, Ning Xia, Ulrich Foerstermann, Huige Li
• Pharmacology
• 2014

BACKGROUND/AIM It has been demonstrated that dexamethasone-induced hypertension can be prevented by the NADPH oxidase inhibitor apocynin. The effect of dexamethasone on NADPH oxidase, however, is… (More)

Endothelial dysfunction in tristetraprolin-deficient mice is not caused by enhanced tumor necrosis factor-α expression.

• Franziska Bollmann, Zhixiong Wu, +9 authors Andrea Pautz
• The Journal of biological chemistry
• 2014

Cardiovascular events are important co-morbidities in patients with chronic inflammatory diseases like rheumatoid arthritis. Tristetraprolin (TTP) regulates pro-inflammatory processes through mRNA… (More)

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein HuR to Preserve Endothelial Cell Function and Delay Atherogenesis.

• Sofia-Iris Bibli, Jiong Yu Hu, +21 authors Ingrid Fleming
• Circulation
• 2018

Background -Hydrogen sulfide (H2S), generated by cystathionine γ lyase (CSE), is an important endogenous regulator of vascular function. The aim of the present study was to investigate the control… (More)

Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase

• Silke Tobias, Alice Habermeier, +5 authors Huige Li
• Journal of geriatric cardiology : JGC
• 2015

OBJECTIVE To find out whether dexamethasone induces an uncoupling of the endothelial nitric oxide synthase (eNOS). METHODS & RESULTS A major cause of eNOS uncoupling is a deficiency of its cofactor… (More)

Social isolation-induced epigenetic changes in midbrain of adult mice.

• Daniel Siuda, Z Wu, +8 authors H Li
• Journal of physiology and pharmacology : an…
• 2014

Social isolation and loneliness increase the risk of death as much as well-established risk factors for mortality such as cigarette smoking and alcohol consumption. The underlying molecular… (More)

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