Daniel Sierra

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OBJECTIVE To determine if brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) can be successfully delivered to transected and repaired peripheral nerves by cross-linking the factors to collagen tubules (CTs). METHODS Forty-eight Sprague-Dawley rats underwent left sciatic nerve transection and repair. In the control group, CTs(More)
The purpose of this study was to investigate the effect of systemic co-injections of ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) on the functional recovery of transected sciatic nerves repaired by epineurial coaptation (EC) or collagen tubulization (CT). Forty Sprague-Dawley rats underwent transection of their sciatic(More)
The goal of this study was to determine the persistence of caprine intramammary pathogens throughout lactation and to detect the bias in diagnoses when a single milk sample was used. We studied 131 goats throughout 7 mo of lactation. Goats were sampled monthly, and 1834 milk samples were bacteriologically analyzed. One hundred sixty-eight pathogens were(More)
Simulation is a powerful tool whose potential has not been fully explored and applied within the Civil Engineering context. Despite Discrete Event Simulation benefits and capabilities, its complex and time consuming elaboration makes it an unpractical choice along this field. This article shows an example regarding earthmoving operations in Civil Engineer(More)
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