Daniel Sejer Pedersen

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GPR139 is an orphan G protein-coupled receptor that is expressed primarily in the brain. Not much is known regarding the function of GPR139. Recently we have shown that GPR139 is activated by the amino acids l-tryptophan and l-phenylalanine (EC50 values of 220 μM and 320 μM, respectively), as well as di-peptides comprised of aromatic amino acids. This led(More)
The title compound, C(27)H(30)O(6), was prepared by monodihydroxy-lation of the bis-olefin (E,E)-tert-butyl 2-acetyl-2-cinnamyl-5-phenyl-pent-4-enoate using standard Sharpless asymmetric dihydroxy-lation conditions, followed by treatment with 1,1'-carbonyl diimidazole. In the crystal structure, the phenyl rings form an intra-molecular edge-to-face C-H⋯π(More)
The title compound, C(28)H(24)N(2)O(5), was prepared from (E)-2-cinnamyl-1,3-diphenyl-propane-1,3-dione using standard Sharpless asymmetric dihydroxy-lation conditions, followed by treatment with 1,1'-carbonyl diimidazole. In the crystal structure, the phenyl rings form inter-molecular face-to-face π-π contacts, with an inter-planar angle of 15.5 (2)° and a(More)
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