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A self-adaptive software system modifies its behavior at runtime in response to changes within the system or in its execution environment. The fulfillment of the system requirements needs to be guaranteed even in the presence of adverse conditions and adaptations. Thus, a key challenge for self-adaptive software systems is assurance. Traditionally,(More)
In recent years it has become more and more evident that the ability of systems to adapt themselves is an increasingly important requirement. This is not least driven by emerging computing trends like Ubiquitous Computing, Ambient Intelligence, and Cyber Physical Systems, where systems have to react on changing user needs, service/device availability and(More)
Posttranslational modification of proteins with ubiquitin (ubiquitylation) regulates numerous cellular processes. Besides functioning as a signal for proteasomal degradation, ubiquitylation has also non-proteolytic functions by altering the biochemical properties of the modified protein. To investigate the effect(s) of ubiquitylation on the properties of a(More)
The conjugation of ubiquitin to proteins plays an important role in the regulation of numerous cellular processes. Deregulation of this pathway has been associated with different human disorders including cancer and neurodege nerative diseases. [2] For ubiquitylation, ubiquitin is initially activated by a ubiquitin activating enzyme (E1) at the expense of(More)