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Iron-containing nucleoside analogues with pronounced apoptosis-inducing activity.
Total synthesis and biological evaluation of halipeptins A and D and analogues.
The marine-derived halipeptins A (1a) and D (1d) and their analogues 3a, 3d and 4a, 4d were synthesized starting from building blocks 10, 13, 14a or 14d, 15, and 16. The first strategy for assemblingExpand
Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues.
The isolation from the marine sponge Leiosella cf. arenifibrosa and structural elucidation of halipeptin D (5), a relative of the previously isolated halipeptins A-C (1-3), is described along withExpand
Nucleoside analogues with a 1,3-diene-Fe(CO)3 substructure: stereoselective synthesis, configurational assignment, and apoptosis-inducing activity.
The synthesis and stereochemical assignment of two classes of iron-containing nucleoside analogues, both of which contain a butadiene-Fe(CO)3 substructure, is described. The first type of compoundsExpand
Iron Containing Nucleosides as New Cytostatic Substances for Cancer and Leukemia Therapy, Especially for Therapy of Relapsed ALL in Childhoodtransfusion of Red Blood Cells under Shock Conditions in
Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Despite a relatively good prognosis approximately one fourth of the patients suffers from relapse and,Expand
Synthesis of Halipeptins A and D