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— Stickybot is a bio-inspired robot that climbs smooth vertical surfaces such as glass, plastic and ceramic tile at 4 cm/s. The robot employs several design principles adapted from the gecko including a hierarchy of compliant structures, directional adhesion, and control of tangential contact forces to achieve control of adhesion. We describe the design and(More)
— Recent biological research suggests that reliable, agile climbing on smooth vertical surfaces requires control-lable adhesion. In nature, geckos control adhesion by properly loading the compliant adhesive structures on their toes. These strongly anisotropic dry adhesive structures produce large frictional and adhesive forces when subjected to certain(More)
Accumulating data suggests that mitochondrial deficits may underline both sporadic and familial Parkinson’s disease (PD) neurodegenerative process. Impairment of mitochondrial dynamics results in reactive oxygen species (ROS) production, decreases mitochondrial membrane potential, and could potentiate the accumulation of dysfunctional mitochondria.(More)
OBJECTIVE The aim of this work was to evaluate the role of ubiquitin-proteasome system (UPS) on mitochondrial-driven alpha-synuclein (aSN) clearance in in vitro, ex vivo and in vivo Parkinson's disease (PD) cellular models. METHOD We used SH-SY5Y ndufa2 knock-down (KD) cells, PD cybrids and peripheral blood mononuclear cells (PBMC) from patients meeting(More)
Mutations in leucine-rich repeat kinase 2 gene (LRRK2) are implicated in autosomal dominant familial and sporadic Parkinson’s disease (sPD). Given its relative frequency in PD and its putative function in several cellular pathways that are known to be impaired in the disease, we wanted to tackle LRRK2 physiological role and to address its potential as a PD(More)
— The adhesive and frictional properties of dry adhesive materials can be described by a three-dimensional limit surface in the space of normal and tangential contact forces at the feet. We present the empirically derived limit surface for directional adhesive pads and illustrate its application to controlling the forces at the feet of a robot climbing on(More)
Nowadays, there is a growing need to automatically extract information from texts. In this active research field much effort has been invested to improve the identification and classification of named entities , the detection of time expressions, and the identification of semantic relations between text entities. This paper presents a system that identifies(More)
Neurotrophic factors (NTFs) promote nerve regeneration and neuronal survival after peripheral nerve injury. However, drawbacks related with administration and bioactivity during long periods limit their therapeutic application. In this study, PLGA microspheres (MPs) were used to locally release different NTFs and evaluate whether they accelerate axonal(More)
After peripheral nerve injury, axons are able to regenerate, although specific sensory reinnervation and functional recovery are usually worse for large myelinated than for small sensory axons. The mechanisms that mediate the regeneration of different sensory neuron subpopulations are poorly known. The Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) is(More)