Daniel S. Schlusselberg

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A technique is described which has been used to quantitate the 3-dimensional configuration of the midbrain dopamine (DA) nuclei (cell groups A8, A9, and A10). This technique provides cell counting information, for example, the BALB/c mouse has approximately 25,000 midbrain DA neurons, the albino rat has about 40,000 neurons, and man (33 year old) has(More)
Computer-aided techniques were used to reconstruct the complex renal tubular system in the dorsal kidney region of a marine elasmobranch fish, the little skate (Raja erinacea), from a series of light micrographs of serial sections. It was established that five individual segments of one nephron, consisting of two loops and a distal tubule, are arranged in(More)
Although three-dimensional computed tomographic angiography was developed as a screening tool for use in patients with suspected cerebrovascular disease, this imaging modality has also proven to be of value in surgical planning for patients with large or unusual vascular lesions of the brain. The three-dimensional images generated by this technique yield(More)
Computer-generated three-dimensional reconstruction of the intracranial vascular system obtained by contrast-enhanced computerized tomography (CT) has been used in the diagnosis of 20 patients with known or suspected intracranial cerebrovascular disease. This technique allows visualization of the intracranial vasculature without exposing patients to the(More)
Computed tomography (CT) can generate a set of serial contiguous slices which form a volume of medical image data. We have developed new techniques for creating computer synthesized 3-D images directly from a volume encoded as a three-dimensional array. The operator can place the eye anywhere in object space to selectively view a portion of the volume from(More)
A group of 23 pediatric patients seropositive for HIV antibody were studied by computed tomography and evaluated neurodevelopmentally. Significant neurodevelopmental delays were found in over 95% of the patients studied. CT findings in six patients were normal and thirteen of 23 (57%) had prominence of the CSF spaces. Less frequent findings included(More)
A group of 23 pediatric patients seropositive for HIV antibody were studied by computed tomography and evaluated neurodevelopmentally. Significant neurodevelopmental delays were found in over 95% of the patients studied. CT findings in six patients were normal and thirteen of 23 (57%) had prominence of the CSF spaces. Less frequent findings included(More)
The precise anatomical relation by which autonomic nerve endings contact gastric epithelial cells to enhance the rate of gastric secretions is not fully understood. The aim of the present study was to clarify this issue by using the technique of serial section reconstruction of areas of the gastric mucosa. The work also explored the possibility of a(More)
A general computer-based system has been developed and implemented for acquiring and viewing medical image data. Originally developed for neuroanatomic studies (1), including investigations of cell topography and connectivity in brainstem nuclei, the system has become a versatile and powerful tool for three-dimensional analysis and display of a variety of(More)