Daniel S Rush

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OBJECTIVE To describe the distribution of plasma homocysteine concentrations in an elderly population and to analyze the relationship between homocysteine level and intake of vitamins and serum levels of vitamins that serve as coenzymes in homocysteine metabolism. DESIGN Cross-sectional analysis of homocysteine levels and vitamin blood levels and intake(More)
This study describes the distribution and determinants of plasma 25-hydroxyvitamin D [25(OH)D] concentrations and risk factors for low 25(OH)D (< or = 37.5 nmol/L) in 290 men and 469 women aged 67-95 y who were in the Framingham Heart Study cohort. Mean (+/-SD) 25(OH)D concentrations were 82 +/- 29 nmol/L in men and 71 +/- 29 nmol/L in women. 25(OH)D was(More)
The dietary patterns of 680 noninstitutionalized, predominantly white, elderly volunteers from the Boston area (447 women and 233 men) were examined by cluster analysis of food contribution to energy intake. Data were derived from 3-day dietary records. The four major patterns identified corresponded to high consumption of (a) alcohol, (b) milk, cereals,(More)
We compared the intake of 12 micronutrients as reported on a semiquantitative food frequency questionnaire with corresponding biochemical indicators of nutrient status in a sample of 57 males and 82 females aged 40-83 y. Age-, sex-and energy-adjusted correlation coefficients ranged from near zero for thiamin, vitamin A, and zinc to 0.63 for folate.(More)
We investigated the relations between plasma concentrations of homocysteine and vitamins B-12 and B-6 and folate, and scores from a battery of cognitive tests for 70 male subjects, aged 54-81 y, in the Normative Aging Study. Lower concentrations of vitamin B-12 (P=0.04) and folate (P=0.003) and higher concentrations of homocysteine (P=0.0009 ) were(More)
BACKGROUND Evidence suggests that pathophysiologic processes in bone are important determinants of outcome in osteoarthritis of the knee. Low intake and low serum levels of vitamin D may compromise favorable responses of bone to osteoarthritis, predisposing patients to progression. OBJECTIVE To determine whether dietary intake and serum levels of vitamin(More)
Duplex ultrasonography was used prospectively in the initial evaluation of 198 patients with 319 potential vascular injuries of the neck and extremities. Patients who were unstable or who had obvious arterial trauma were excluded. Injury was caused by gunshot in 104 (53%), blunt trauma in 42 (21%), stab wound in 34 (17%), and shotgun in 18 (9%). Duplex(More)
BACKGROUND Carotid body tumor (CBT) is a rare lesion of the neuroendocrine system. Chronic hypoxia has long been recognized as an etiology of CBT and other paragangliomas. Recent biogenetic discoveries reveal that mutations in oxygen-sensing genes are another etiology, accounting for approximately 35% of cases, and that these 2 etiologies are probably(More)
Previous studies of the vitamin D receptor (VDR) polymorphisms and bone mineral density (BMD) have suggested that there may be differences in calcium absorption among groups of women with different VDR genotypes, and that the association may be stronger in younger women. To investigate the association between the VDR polymorphisms and BMD, this study was(More)
OBJECTIVE Cumulative damage to tissues, mediated by reactive oxygen species, has been implicated as a pathway that leads to many of the degenerative changes associated with aging. We hypothesized that increased intake of antioxidant micronutrients might be associated with decreased rates of osteoarthritis (OA) in the knees, a common age-related disorder. (More)