Daniel S Leventhal
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Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
On the Origin of Tumor Tregs The tumor microenvironment is often seeded with regulatory T cells (Tregs), which inhibit antitumor immunity. Using mice with genetically driven prostate cancer, Malchow… Expand
Shaping the repertoire of tumor‐infiltrating effector and regulatory T cells
Many tumors express antigens that can be specifically or selectively recognized by T lymphocytes, suggesting that T‐cell‐mediated immunity may be harnessed for the immunotherapy of cancer. However,… Expand
Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage.
- Sven Malchow, Daniel S Leventhal, Victoria Lee, Saki Nishi, N. Socci, P. A. Savage
- Medicine, Biology
- 17 May 2016
The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), is critical for the protection of peripheral tissues from autoimmune attack.… Expand
Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells.
Although antigen recognition mediated by the T cell receptor (TCR) influences many facets of Foxp3(+) regulatory T (Treg) cell biology, including development and function, the cell types that present… Expand
Basic principles of tumor-associated regulatory T cell biology.
Due to the critical role of forkhead box (Fox)p3(+) regulatory T cells (Tregs) in the regulation of immunity and the enrichment of Tregs within many human tumors, several emerging therapeutic… Expand
Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We… Expand
Re: Aire-dependent thymic development of tumor-associated regulatory T cells
Abstract LB-131: Activation of innate and adaptive immunity via combinatorial immunotherapy using Synthetic Biotic™ Medicines
Background: While both T-cell priming and blockade of immune suppression play critical roles in the generation of an efficacious antitumor immune response, most therapies fail to support both… Expand
Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance
- Brendan W MacNabb, Douglas E. Kline, +4 authors J. Kline
- Medicine, Biology
- The Journal of Immunology
- 1 May 2019
Deletion of CD8+ T cells by dendritic cells (DCs) is recognized as a critical mechanism of immune tolerance to self-antigens. Although DC-mediated peripheral deletion of autoreactive CD8+ T cells has… Expand