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Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
On the Origin of Tumor Tregs The tumor microenvironment is often seeded with regulatory T cells (Tregs), which inhibit antitumor immunity. Using mice with genetically driven prostate cancer, MalchowExpand
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Shaping the repertoire of tumor‐infiltrating effector and regulatory T cells
Many tumors express antigens that can be specifically or selectively recognized by T lymphocytes, suggesting that T‐cell‐mediated immunity may be harnessed for the immunotherapy of cancer. However,Expand
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Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage.
The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), is critical for the protection of peripheral tissues from autoimmune attack.Expand
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Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells.
Although antigen recognition mediated by the T cell receptor (TCR) influences many facets of Foxp3(+) regulatory T (Treg) cell biology, including development and function, the cell types that presentExpand
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Basic principles of tumor-associated regulatory T cell biology.
Due to the critical role of forkhead box (Fox)p3(+) regulatory T cells (Tregs) in the regulation of immunity and the enrichment of Tregs within many human tumors, several emerging therapeuticExpand
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Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. WeExpand
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Abstract LB-131: Activation of innate and adaptive immunity via combinatorial immunotherapy using Synthetic Biotic™ Medicines
Background: While both T-cell priming and blockade of immune suppression play critical roles in the generation of an efficacious antitumor immune response, most therapies fail to support bothExpand
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Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance
Deletion of CD8+ T cells by dendritic cells (DCs) is recognized as a critical mechanism of immune tolerance to self-antigens. Although DC-mediated peripheral deletion of autoreactive CD8+ T cells hasExpand
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