Daniel S Kessler

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Beginning in the mid-2000s, the incidence of drug shortages rose, especially for generic injectable drugs such as anesthetics and chemotherapy treatments. We examine whether reimbursement changes contributed to the shortages, focusing on a reduction in Medicare Part B reimbursement to providers for drugs. We hypothesize that lower reimbursement put downward(More)
Due to its association with Merkel cell carcinoma (MCC), a substantial effort has been made to better understand how Merkel cell polyomavirus (MCPyV) proteins drive oncogenesis; however, our understanding of the early steps of MCPyV infection remains poor. The polyomavirus Large Tumor antigen (LT) is a highly multi-functional protein with a wide range of(More)
Crudele, Julie Marie, "Adeno-associated viral vector-driven expression of coagulation proteins for treatment of hemophilias and cancer" (2015). Abstract Treatment of hemophilia, which involves infusion of the missing clotting factor, is often hindered by the development of neutralizing antibodies to the replaced clotting factor. We utilized liver-directed(More)
HIV-1 strains that use CCR5 predominate after transmission and during the asymptomatic period of disease. However, in up to half of infected people, variants that use CXCR4 emerge, coincident with accelerated disease progression. The earliest CXCR4 using strains to appear, called R5X4 viruses, usually retain CCR5 use. Prototype R5X4 HIV-1 isolates infect(More)
The transcription factor ATF4 regulates the expression of mRNAs involved in amino acid metabolism, redox homeostasis and ER stress responses. Its overexpression in human solid tumors suggests an important role in tumor biology. Here we report that inhibition of ATF4 expression blocks proliferation and survival of transformed cells, despite an initial(More)
Cells react to diverse stimuli by expressing specific receptors that recognize these stimuli and initiate specific signaling pathways that enable a cell to change with the environment. Downregulation of these signaling receptors represents the most direct method for limiting the magnitude and duration of downstream signal transduction. For cell surface(More)
The adenovirus (Ad) vector is an attractive candidate for vaccines designed to elicit cellular immunity as studies in animals and humans have proven Ad vectors are capable of inducing large transgene-specific T-cell responses. However, given that natural infection by Ad is prevalent globally, pre-existing Ad immunity is a major impediment to the use of(More)
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