Daniel S. Dombrowski

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We have shown previously that intrathecal (i.t.) administration of the combination of delta 9-tetrahydrocannabinol (THC) and morphine results in a greater than additive antinociceptive effect. Similarly, pretreating mice with subthreshold doses of the kappa agonist, Dynorphin A (1-8), produced a parallel, leftward shift of the morphine dose-response curve,(More)
Opioid analgesic tolerance is associated with a disruption in Ca++ homeostasis. Drugs reducing Ca++ influx can prevent and reverse tolerance. The hypothesis was tested that both Ca++ influx and mobilization from intracellular pools maintains the expression of morphine tolerance. Ca++ modulating drugs were injected ICV at doses not affecting morphine's(More)
Calcitonin gene-related peptide (CGRP) and the selective antagonist properties of the peptide fragment of CGRP [CGRP (8-37)] have been the subjects of numerous investigations. These data represent the first demonstration of the hypothermic and antinociceptive effects of CGRP (8-37). Intrathecal injection of CGRP (8-37) in mice produced hypothermia which(More)
In studying the interactions between handling mice and their subsequent analgesic response to an intrathecally (i.t.) administered mu-opioid agonist, DAMGO, it was found that suspending ICR mice by the tail for 1, 5, or 20 sec, 10 min before the tail-flick test, enhanced DAMGO by 5.3-, 7.4- and 23.6-fold, respectively, compared with mice maintained in a(More)
Despite the promise of hematological parameters and blood chemistry in monitoring the health of marine fishes, baseline data is often lacking for small fishes that comprise central roles in marine food webs. This study establishes blood chemistry and hematological baseline parameters for the pinfish Lagodon rhomboides, a small marine teleost that is among(More)
Ectothermic vertebrates are a diverse group of animals that rely on external sources to maintain a preferred body temperature. Amphibians and reptiles have a preferred optimal temperature zone that allows for optimal biological function. Physiologic processes in ectotherms are influenced by temperature; these animals have capabilities in which they make use(More)
Chytridiomycosis is an often fatal fungal disease of amphibians caused by Batrachochytrium dendrobatidis. This disease has been implicated in the worldwide decline of many anuran species, but studies of chytridiomycosis in wild salamanders are limited. Between August 2006 and December 2006, we tested wild amphibians in North Carolina, USA (n=212) by(More)
An adult male two-toed amphiuma (Amphiuma means) was evaluated for kyphosis and a self-inflicted ulcerative dermal lesion at the site of a midbody spinal deformity. Radiology revealed a proliferative bony lesion at the 39th vertebra. A dorsal laminectomy was performed to alleviate pressure on the spinal cord believed to be secondary to bone remodeling.(More)
The hypoglycemic effect of morphine (40 micrograms) injected intrathecally (i.t.) was studied with regard to disposition of i.v. [14C]glucose and [3H]2-deoxyglucose and was compared with the effects of two other hypoglycemic agents, insulin (1 IU/kg, s.c.) and xanthan gum (50 mg/kg, i.p.). Mice given i.t. morphine or s.c. insulin exhaled a greater amount of(More)
Invertebrate species are commonly kept as pets as well as display and research animals. Clinicians interested in zoologic medicine should be prepared to provide veterinary care for these interesting creatures. This article provides an overview on the critical care of commonly encountered invertebrate species.