Daniel Ruiz-González

Learn More
The design and development of any complex applications using a Model-driven Engineering approach involve not only the use of many models, but also the use of many model transformations between them. These transformations should be chained together, using Model Transformation Orchestration notations and tools. This paper introduces Wires*, a graphical(More)
Twenty patients with severe aplastic anemia (SAA) were treated with low doses (1-5 mg/kg/day) of a high-potency antithymocyte globulin (ATG) produced in Mexico, shown to have at least a 10-fold potency as compared with other globulins of commercial sources. Patients received ATG within a 10-day period, every other day (5 doses) at a dose of 1 mg/kg/day (4(More)
Viewpoint modeling has demonstrated to be an effective approach for specifying complex software systems by means of a set of independent views and correspondences between them. As any other software system, a Web application evolves during its lifetime, and its specifications change to meet new requirements or to adapt to business changes. As a consequence,(More)
Cervical carotid artery dissections (CCAD) are common in young adults with a mean age of 44 years and may account for as many as 20% of strokes in patients younger than 30 years. Trauma and primary diseases of the arterial wall such as fibromuscular dysplasia are the main predisposing factors. Some CCAD cases are diagnosed solely on clinical history and(More)
Acute megakaryoblastic leukaemia, the M-7 variant of acute leukaemia according to the French-American-British (FAB) co-operative group, comprises 8.4% of all cases of acute leukaemia in the city of Puebla, Mexico. The malignancy can be identified by means of monoclonal antibodies or electron microscopy. Using two monoclonal antibodies, Hp1-1d that binds the(More)
There are both advantages and disadvantages of using visual and textual notations for expressing large system specifications. Each kind of notation seems to be more apt for expressing and managing some aspects, and there is no clear winner. A solution can be the use of both styles, with synchronization mechanisms that always keep them in synch. In this(More)
  • 1