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- C. Fleury, Maria Neverova, +8 authors Craig H Warden
- Nature Genetics
- 1997
A mitochondrial protein called uncoupling protein (UCP1) plays an important role in generating heat and burning calories by creating a pathway that allows dissipation of the proton electrochemical… (More)
- Denis Arsenijevic, Hiroki Onuma, +11 authors Daniel Ricquier
- Nature Genetics
- 2000
The gene Ucp2 is a member of a family of genes found in animals and plants, encoding a protein homologous to the brown fat uncoupling protein Ucp1 (refs 1–3). As Ucp2 is widely expressed in mammalian… (More)
- Daniel Ricquier, Frédéric Bouillaud
- The Biochemical journal
- 2000
Animal and plant uncoupling protein (UCP) homologues form a subfamily of mitochondrial carriers that are evolutionarily related and possibly derived from a proton/anion transporter ancestor. The… (More)
- Claire Pecqueur, Marie Clotilde Alves-Guerra, +6 authors Bruno Miroux
- The Journal of biological chemistry
- 2001
Uncoupling protein 2 (UCP2) belongs to the mitochondrial anion carrier family and partially uncouples respiration from ATP synthesis when expressed in recombinant yeast mitochondria. We generated a… (More)
- Beatrice Cousin, Saverio Cinti, +4 authors Louis Casteilla
- Journal of cell science
- 1992
Brown adipocytes are thermogenic cells which play an important role in energy balance. Their thermogenic activity is due to the presence of a mitochondrial uncoupling protein (UCP). Until recently,… (More)
- Anna Coppola, Zhong-wu Liu, +8 authors Sabrina Diano
- Cell metabolism
- 2007
The active thyroid hormone, triiodothyronine (T3), regulates mitochondrial uncoupling protein activity and related thermogenesis in peripheral tissues. Type 2 deiodinase (DII), an enzyme that… (More)
- Angelo Vozza, Giovanni Parisi, +12 authors Giuseppe Fiermonte
- Proceedings of the National Academy of Sciences…
- 2014
Uncoupling protein 2 (UCP2) is involved in various physiological and pathological processes such as insulin secretion, stem cell differentiation, cancer, and aging. However, its biochemical and… (More)
- Laurence Millet, Hubert Vidal, +5 authors Dominique Langin
- The Journal of clinical investigation
- 1997
Uncoupling protein-2 and -3 (UCP2 and UCP3) are mitochondrial proteins that show high sequence homology with the brown adipocyte-specific UCP1. UCP1 induces heat production by uncoupling respiration… (More)
- Serge Raimbault, Sami Dridi, +7 authors Daniel Ricquier
- The Biochemical journal
- 2001
The cDNA of an uncoupling protein (UCP) homologue was obtained by screening a chicken skeletal-muscle library. The predicted 307-amino-acid sequence of avian UCP (avUCP) is 55, 70, 70 and 46%… (More)
- Daniel Ricquier, Frédéric Bouillaud
- The Journal of physiology
- 2000
The coupling of oxygen consumption to ADP phosphorylation is incomplete, as is particularly evident in brown adipocyte mitochondria which use a regulated uncoupling mechanism to dissipate heat… (More)