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Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase
During eukaryotic DNA interstrand cross-link (ICL) repair, cross-links are resolved ("unhooked") by nucleolytic incisions surrounding the lesion. In vertebrates, ICL repair is triggered whenExpand
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Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites
During pre-mRNA splicing, a central step in the expression and regulation of eukaryotic genes, the spliceosome selects splice sites for intron excision and exon ligation. In doing so, the spliceosomeExpand
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TRAIP is a master regulator of DNA interstrand cross-link repair
Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway has substantial implications for the fidelity of genome maintenance. DNA interstrand crosslinks covalentlyExpand
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Staying on message: ensuring fidelity in pre-mRNA splicing.
The faithful expression of genes requires that cellular machinery select substrates with high specificity at each step in gene expression. High specificity is particularly important at the stage ofExpand
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Parallel Selections In Vitro Reveal a Preference for 2′–5′ RNA Ligation upon Deoxyribozyme-Mediated Opening of a 2′,3′-Cyclic Phosphate
We previously used in vitro selection to identify Mg2+-dependent deoxyribozymes that mediate the ligation reaction of an RNA 5′-hydroxyl group with a 2′,3′-cyclic phosphate. In these efforts, all ofExpand
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Structure-function correlations derived from faster variants of a RNA ligase deoxyribozyme.
We previously reported the in vitro selection of several Mg2+-dependent deoxyribozymes (DNA enzymes) that synthesize a 2'-5' RNA linkage from a 2',3'-cyclic phosphate and a 5'-hydroxyl. Here weExpand
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