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When modeling single-molecule fluorescence lifetime experimental data, the analysis often involves fitting a biexponential distribution to binned data. When dealing with small sample sizes, there is the potential for convergence failure in numerical optimization, for convergence to local optima resulting in physically unreasonable parameter estimates, and(More)
Introduction The knowledge domains of basic research in the sciences as well as applied research & practice domains including engineering, advanced information technology, and education are in modes of explosive growth. There is a strong need for, yet it is difficult to sustain, effective collaborations which would benefit the groups focused on each domain.(More)
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