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Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures.

• Julie A. Lemm, John E. Leet, +12 authors Min Gao
• Antimicrobial agents and chemotherapy
• 2011

The exceptional in vitro potency of the hepatitis C virus (HCV) NS5A inhibitor BMS-790052 has translated into an in vivo effect in proof-of-concept clinical trials. Although the 50% effective… (More)

The biosynthetic origins of rebeccamycin.

• Cedric J. Pearce, Terrence W. Doyle, Salvatore Forenza, Kin Sing Lam, Daniel R Schroeder
• Journal of natural products
• 1988

Experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by Saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of… (More)

Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. III. Structural elucidation.

• John E. Leet, Daniel R Schroeder, +7 authors Bala S. Krishnan
• The Journal of antibiotics
• 1996

The structure of the antitumor antibiotic himastatin was determined using a combination of spectroscopic and chemical degradation techniques. Himastatin is a unique dimeric cyclohexadepsipeptide… (More)

Himastatin, a new antitumor antibiotic from Streptomyces hygroscopicus. II. Isolation and characterization.

• John E. Leet, Daniel R Schroeder, Bala S. Krishnan, James A. Matson
• The Journal of antibiotics
• 1990

The novel antitumor antibiotic himastatin was isolated from cultured broth of Streptomyces hygroscopicus (ATCC 53653) and purified by vacuum liquid chromatography, column chromatography, and… (More)

Selective proteolytic activity of the antitumor agent kedarcidin.

• Nizar N. Zein, Anna Maria Casazza, +4 authors Steven G. Nadler
• Proceedings of the National Academy of Sciences…
• 1993

Kedarcidin is a potent antitumor antibiotic chromoprotein, composed of an enediyne-containing chromophore embedded in a highly acidic single chain polypeptide. The chromophore was shown to cleave… (More)

Production, isolation and structure determination of novel fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243.

• Kin Sing Lam, Daniel R Schroeder, +5 authors Salvatore Forenza
• The Journal of antibiotics
• 2001

Saccharothrix aerocolonigenes ATCC 39243 produces an indolocarbazole antitumor agent rebeccamycin under submerged fermentation conditions. Adding DL-6-fluorotryptophan to culture of S.… (More)

Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis.

• Daniel R Schroeder, Kim L Colson, +4 authors Jon Clardy
• The Journal of antibiotics
• 1996

Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp.… (More)

Maduropeptin: an antitumor chromoprotein with selective protease activity and DNA cleaving properties.

• Nizar N. Zein, William Solomon, Kim L Colson, Daniel R Schroeder
• Biochemistry
• 1995

Maduropeptin (MDP) is a recently isolated antitumor antibiotic, consisting of an enediyne-containing chromophore embedded in a highly acidic protein. This holoantibiotic damages duplex DNA in vitro,… (More)

Isolation of a bromo analog of rebeccamycin from Saccharothrix aerocolonigenes.

• Kin Sing Lam, Daniel R Schroeder, Jacqueline M. Veitch, James A. Matson, Salvatore Forenza
• The Journal of antibiotics
• 1991

When grown in a defined medium containing 0.05% KBr, Saccharothrix aerocolonigenes ATCC 39243 produces a novel bromo analog of rebeccamycin. This new analog, designated bromorebeccamycin, has been… (More)

Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.

• Nizar N. Zein, Kim L Colson, +4 authors Anna Maria Casazza
• Proceedings of the National Academy of Sciences…
• 1993

Kedarcidin chromophore is a 9-membered enediyne, recently isolated from an actinomycete strain. In vivo studies show this molecule to be extremely active against P388 leukemia and B16 melanoma.… (More)

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