Learn More
The hematologic consequences of infection with the noncytopathic lymphocytic choriomen-ingitis virus (LCMV) were studied in wild-type mice with inherent variations in their inter-feron (IFN)-␣ / ␤ responder ability and in mutant mice lacking ␣ / ␤ (IFN-␣ / ␤ R 0/0) or ␥ IFN (IFN-␥ R 0/0) receptors. During the first week of infection, wild type mice(More)
Progressive supranuclear palsy (PSP) is a neurodegenerative movement disorder of unknown etiology. We hypothesized that mitochondrial DNA (mtDNA) aberration could occur in this disease and contribute to its pathogenesis. To address this we created transmitochondrial cytoplasmic hybrid (cybrid) cell lines expressing mitochondrial genes from persons with PSP.(More)
Aplastic anemia may be associated with persistent viral infections that result from failure of the immune system to control virus. To evaluate the effects on hematopoiesis exerted by sustained viral replication in the presence of activated T cells, blood values and bone marrow (BM) function were analyzed in chronic infection with lymphocytic(More)
Complex I activity is reduced in cytoplasmic hybrid (cybrid) cell lines that contain mitochondrial DNA (mtDNA) from sporadic Parkinson's disease (PD) patients. This implies that mtDNA aberration occurs in sporadic PD. To assess the integrity of mtDNA in autosomal dominant PD arising from mutation of the alpha-synuclein gene, we transferred mitochondrial(More)
The mitochondrial DNA (mtDNA) depletion status of rho(0) cell lines is typically assessed by hybridization or polymerase chain reaction (PCR) experiments, in which the failure to hybridize mtDNA or amplify mtDNA using mtDNA-directed primers suggests thorough mitochondrial genome removal. Here, we report the use of an mtDNA pseudogene ratioing technique for(More)
Lung cancer is one of the leading causes of death in industrialized and developing countries. Approximately 80% of patients are diagnosed with non-small cell histology. Although a multidisciplinary approach is necessary for the treatment of patients at early or locally-advanced stages of the disease, further successes in the treatment of patients with(More)
Engineers in the automotive domain are confronted with a huge load of information making it difficult for them to identify the information relevant for performing their tasks. Particularly challenging is the alignment of process information, such as offices files, checklists, and guidelines with business processes. In previous work, we introduced the(More)
  • 1