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BACKGROUND The cytochrome P450 3A4 (CYP3A4) inhibitor clarithromycin may also inhibit liver-specific organic anion-transporting polypeptides (OATP1B1 and OATP1B3). We studied whether concurrent use of clarithromycin and a statin not metabolized by CYP3A4 was associated with an increased frequency of serious adverse events. METHODS Using large health care(More)
Obstructive sleep apnea (OSA) is a highly prevalent chronic sleep disorder associated with considerable systemic and ophthalmic consequences. The authors present the retinal vascular findings of a visually asymptomatic 56-year-old man clinically diagnosed with OSA using swept-source optical coherence tomography and vascular perfusion mapping. [Ophthalmic(More)
BACKGROUND AND OBJECTIVE To assess the utility of swept-source optical coherence tomography (SS-OCT) in visualizing macular hole (MH) closure through gas-filled eyes on postoperative day (POD) 1 using a dual scanning protocol. PATIENTS AND METHODS We examined 30 consecutive patients with full-thickness MH who underwent standard vitrectomy with SF6 (25%)(More)
BACKGROUND Compared to Caucasians, Chinese achieve a higher blood concentration of statin for a given dose. It remains unknown whether this translates to increased risk of serious statin-associated adverse events amongst Chinese patients. METHODS We conducted a population-based retrospective cohort study of older adults (mean age, 74 years) newly(More)
An 85-year-old woman with stage IV breast cancer was referred for gradually progressive blurred vision. Dilated fundus examination revealed unifocal, yellow, round vitelliform lesions in the macular region of both eyes. The diagnosis of acute exudative paraneoplastic polymorphous vitelliform maculopathy (AEPPVM) was confirmed with swept-source optical(More)
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