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Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
TLDR
Findings identify hnRNPA2B1 as a key player in miRNA sorting into exosomes and provide potential tools for the packaging of selected regulatory RNAs into exOSomes and their use in biomedical applications. Expand
Translation of CircRNAs
TLDR
This study provides strong evidence for translation of circRNAs, revealing the existence of an unexplored layer of gene activity. Expand
The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes*
TLDR
Intracellular TEM interactome is characterized by high throughput mass spectrometry, in both human lymphoblasts and their derived exosomes, revealing a clear pattern of interaction networks and providing evidence that insertion into TEM may be necessary for protein inclusion into the exosome structure. Expand
CD81 regulates cell migration through its association with Rac GTPase
TLDR
Evidence is provided for a new direct interaction of the GTPase Rac with the C-terminal cytoplasmic domain of tetraspanin CD81, which provides a novel mechanism for regulation of cell motility by tetrascanins. Expand
EWI-2 Association with α-Actinin Regulates T Cell Immune Synapses and HIV Viral Infection
TLDR
The data suggest that the EWI-2–α-actinin complex is involved in the regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition. Expand
General statistical framework for quantitative proteomics by stable isotope labeling.
TLDR
This work presents a generally applicable model that accurately explains the behavior of data obtained using current SIL approaches, including (18)O, iTRAQ, and SILAC labeling, and different MS instruments, and decomposes the total technical variance into the spectral, peptide, and protein variance components. Expand
Na+/K+-ATPase Is a New Interacting Partner for the Neuronal Glycine Transporter GlyT2 That Downregulates Its Expression In Vitro and In Vivo
TLDR
The ouabain-mediated downregulation of GlyT2 also occurs in vivo in two different systems: zebrafish embryos and adult rats, indicating that this NKA-mediated regulatory mechanism is evolutionarily conserved and may play a relevant role in the physiological control of inhibitory glycinergic neurotransmission. Expand
Initiation of acute graft-versus-host disease by angiogenesis.
TLDR
It is shown that angiogenesis precedes leukocyte infiltration in experimental models of inflammatory bowel disease and acute graft-versus-host disease (GVHD) and that metabolic changes trigger alterations in cell mechanics, leading to enhanced migratory and proliferative potential of ECs during the initiation of inflammation. Expand
A Robust Method for Quantitative High-throughput Analysis of Proteomes by 18O Labeling*
TLDR
An improved high-throughput quantitative proteomics method based on whole proteome concentration by SDS-PAGE, optimized in-gel digestion, peptide 18O-labeling, and separation by off-gel isoelectric focusing followed by liquid chromatography-LIT-MS is presented. Expand
The Leukocyte Activation Receptor CD69 Controls T Cell Differentiation through Its Interaction with Galectin-1
TLDR
This work has detected the presence of a ligand(s) for CD69 on human dendritic cells (DCs) and identified galectin-1 as a CD69 counterreceptor. Expand
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