Daniel P Zollinger

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AIMS An integrated population pharmacokinetic-pharmacodynamic model was developed with the following aims: to simultaneously describe pharmacokinetic behaviour of sugammadex and rocuronium; to establish the pharmacokinetic-pharmacodynamic model for rocuronium-induced neuromuscular blockade and reversal by sugammadex; to evaluate covariate effects; and to(More)
A procedure is proposed for the determination of malononitrile by differential pulse polarography in methanolic 0.1M tetraethylammonium iodide/0.001M tetramethylammonium hydroxide as the supporting electrolyte. In this medium malononitrile is chemically converted into an electroactive species. With close control of timing of the steps in the procedure the(More)
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