Daniel N Mori

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Aging leads to a proinflammatory state within the vasculature without disease, yet whether this inflammatory state occurs during atherogenesis remains unclear. Here, we examined how aging impacts atherosclerosis using Ldlr(-/-) mice, an established murine model of atherosclerosis. We found that aged atherosclerotic Ldlr(-/-) mice exhibited enhanced(More)
RATIONALE Early graft inflammation enhances both acute and chronic rejection of heart transplants, but it is unclear how this inflammation is initiated. OBJECTIVE To identify specific inflammatory modulators and determine their underlying molecular mechanisms after cardiac transplantation. METHODS AND RESULTS We used a murine heterotopic cardiac(More)
  • W M Keck Biotechnology, Resource Laboratory, +10 authors Daniel Kreisel
  • 2015
In the latter, the harvest and subsequent preservation of an organ induces isch-emic injury to the transplant, which is exacerbated at organ implantation by restoration of blood flow, a condition known as ischemia reperfusion injury (IRI). 4 IRI, in turn, induces in-tragraft inflammation, which can have detrimental effects on long-term allograft function. 5(More)
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