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We evaluated the productions of an artist with frontotemporal lobar degeneration from before dementia onset until she was fully symptomatic. We noted an improvement of technique that might be related to sparing and disinhibition of the right posterior neocortex. There was a reduction of closure (completeness of the painting), possibly induced by(More)
Several advances in large data set collection and processing have the potential to provide a wave of new insights and improvements in the use of radiation therapy for cancer treatment. The era of electronic health records, genomics, and improving information technology resources creates the opportunity to leverage these developments to create a learning(More)
BACKGROUND/OBJECTIVES Patients with Parkinson disease (PD) exhibit motor and frontal-executive dysfunction and often seem to be emotionally apathetic. We investigated whether PD patients have alterations in their emotional reactivity and how this might impact their proximal (avoidance) versus distal (approach) allocation of attention-intention. METHODS(More)
Brain metastases from gastrointestinal (GI) primary malignancies are generally less common than those arising from other primary locations. Our purpose was to analyze the efficacy of stereotactic radiosurgery (SRS) in the treatment of patients with brain metastases from GI malignancies in the modern radiosurgical and systemic therapy era. A review of(More)
Leptomeningeal disease (LMD) is a highly aggressive and usually rapidly fatal condition. The purpose of this study is to identify clinical factors that can serve to predict for LMD at the time of stereotactic radiosurgery (SRS) for brain metastases from breast carcinoma. We conducted a retrospective review of patients with brain metastases from breast(More)
OBJECTIVE Stereotactic radiosurgery (SRS) achieves excellent local control (LC) with limited toxicity for most brain metastases. SRS dose prescription variables influence LC; therefore, we evaluated the impact of prescription isodose line (IDL) on LC after SRS. METHODS A retrospective analysis of patients with brain metastases treated on a Gamma Knife(More)
The recent study by Pan et al (1) has raised concerns within the American radiation oncology (RO) trainee community. The authors update supply and demand projections for RO in the United States. Whereas projections several years ago forecasted an undersupply of radiation oncologists (ROs), the study cites updated data for the proposition that supply will(More)
OBJECTIVE Most evidence describing outcomes of patients with brain metastases is based upon the number of brain metastases, rather than location or volume. We sought to evaluate the impact of tumor location and each location's relative volume on overall survival (OS) among a large cohort of patients treated with stereotactic radiosurgery (SRS). METHODS(More)
OBJECTIVE Although brainstem metastases are thought to portend an inferior prognosis compared to non-brainstem brain metastases, there is limited evidence to support this claim, particularly in the modern radiosurgical era. METHODS We collected the clinical data for 500 patients with brain metastases treated at our institution with stereotactic(More)
Prostate cancer is the most common malignancy found in North American and European men and the second most common cause of cancer related death. Since the practice of PSA screening has become common the disease is most often found early and can have a long indolent course. Current definitive therapy treats the whole gland but has considerable long-term side(More)