Daniel M. Baker

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Rats fed either a diet containing 500 ppm (parts per million) Pb (as lead acetate) or an unadulterated control diet for 50 days were offered a 15% ethanol (ETOH) solution in a nonchoice (one-bottle) test situation. The results from this test indicated that Pb-diet animals consumed greater amounts of the ETOH solution than did controls. In a subsequent(More)
BACKGROUND C57BLKS/J (BLKS) mice are susceptible to islet exhaustion in insulin-resistant states as compared with C57BL6/J (B6) mice, as observed by the presence of the leptin receptor (Lepr) allele, Leprdb/db. Furthermore, DBA2/J (DBA) mice are also susceptible to beta-cell failure and share 25% of their genome with BLKS; thus the DBA genome may contribute(More)
Adult rats fed daily rations of laboratory chow with added CdCl2 were tested for schedule controlled responding and conditioned suppression (conditioned emotional response-CER). Determinations of tissue Cd, levels of metallothionein, and the ratio of Cd in the tissue to the Cd-binding capacity of metallothionein also were made. Animals were exposed daily to(More)
Rats were maintained on an ad lib diet containing 100 ppm cadmium (Group Cadmium-Diet) or a control diet with no added cadmium (Group Control-Diet). After 55 days of exposure to their respective diets, animals were tested for fluid intake using a nonchoice procedure that presented a 15% ethanol solution in the home cage for 5 days. Subsequently, all animals(More)
Step-down passive avoidance acquisition and 24 h retention performance were examined in adult rats given daily doses of either 0, 1, or 5 mg/kg cadmium (Cd) (as CdCl2) via the diet. Results indicated that subjects exposed to the 5 mg/kg Cd diet were less likely to step off a safe platform onto an electrified grid floor than controls. The 1 mg/kg subjects(More)
Cadmium (Cd) levels were measured in 13 dissected brain regions of adult male rats from 3 treatment groups. Rats (approximately 200 g each) were each fed 10 g/day of diets containing either 20 or 100 micrograms/g (ppm) Cd or control diet to which no Cd was added but contained approximately 0.35 ppm Cd. After 67 days of treatment, the brain of each rat was(More)
Background Immunotherapies have improved patient responses and survival , though not all patients benefit. Effective biomarkers may help to improve outcomes. Durvalumab is a human IgG1 mono-clonal antibody that inhibits PD-L1 binding to PD-1 and CD80, restoring antitumor immunity [1, 2]. PD-L1 expression on tumor or tumor-infiltrating immune cells measured(More)
Rats were exposed ad libitum to a diet containing either 500 ppm lead (Group Lead-Diet) or a control diet with no added lead (Group Control-Diet). On Day 60 both groups were presented with a 15% ethanol solution (nonchoice test) in the home cage for five days prior to placement on a choice test that presented animals with a 10% ethanol solution and tap(More)
Adult male rats were fed either 0, 10, or 20 mg Ni/kg body weight (as NiCl2) via a 10 g daily food ration. Following 14 days of exposure, animals were trained over a period of 61 days to lever press for food on a VI-2 operant training schedule while continuing to experience the indicated daily doses. Those rats treated with 20 mg/kg Ni lever pressed at a(More)
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