Daniel Long

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The clinical efficacy of opioid receptor antagonists for the treatment of opioid-induced constipation (OIC) is established. Peripherally selective antagonists are intended to provide OIC symptom relief without compromising the analgesic effects of centrally penetrant opioid agonists. We describe the in vitro profile of a novel opioid receptor antagonist,(More)
Traditional genetic programming only supports the use of arithmetic and logical operators on scalar features. The GTMOEP (Georgia Tech Multiple Objective Evolutionary Programming) framework builds upon this by also handling feature vectors, allowing the use of signal processing and machine learning functions as primitives, in addition to the more(More)
The in vivo preclinical pharmacodynamic profile of TD-1211, a selective opioid receptor antagonist currently under development for the treatment of opioid-induced constipation, was compared to that of the clinically studied opioid antagonists, naltrexone, alvimopan, and ADL 08-0011 (the primary active metabolite of alvimopan). The oral activity of TD-1211(More)
Clustering and nearest neighbor searches in high dimensions are fundamental components of computational geometry, computational statistics, and pattern recognition. Despite the widespread need to analyze massive datasets, no MPI-based implementations are available to allow this analysis to be scaled to modern highly parallel platforms. We seek to develop a(More)
Traditional genetic programming only supports the use of arithmetic and logical operators on scalar features. The GTMOEP (Georgia Tech Multiple Objective Evolutionary Programming) framework builds upon this by also handling feature vectors, allowing the use of signal processing and machine learning functions as primitives, in addition to the more(More)
BACKGROUND Ultrasound induces mechanical vibration and heat, causing differentiation and proliferation in osteoblasts. All known in vitro evaluations of ultrasound are, however, performed with longitudinal ultrasound waves. We addressed a question: Do other forms of ultrasound waves, such as guided waves (longitudinal and guided flexural) transduced at a(More)
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