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It was previously suggested that the 25-Vitamin-D3-1alpha-hydroxylase (CYP27B1) is downregulated during human prostate tumor pathogenesis while the catabolic 25-Vitamin-D3-24-hydroxylase (CYP24) expression is increased. The latter could lead to resistance against the antimitotic, pro-differentiating activity of 1,25-dihydroxycholecalciferol. Our hypothesis(More)
The antimitotic and prodifferentiating 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3), synthesized at various extrarenal sites could potentially prevent sporadic tumor development. Physiological regulation of extrarenal Vitamin D hydroxylases following tissue accumulation of 1alpha,25-(OH)2D3 is unknown. We therefore investigated basal and Vitamin(More)
While Vitamin D insufficiency in the US and European population is rising, epidemiological studies suggest an inverse correlation between low serum levels of 25-hydroxyvitamin D(3) (25-OH-D(3)) and colorectal cancer incidence. The antimitotic, prodifferentiating and proapoptotic active metabolite 1alpha,25-dihydroxyvitamin D(3) (1,25-(OH)(2)-D(3)) is(More)
Soybean products are highly represented in the traditional Asian diet. Major components of soy proteins are phytoestrogens, such as isoflavones. They may be responsible for the extremely low incidence of prostate and mammary tumors and possibly also of colon cancer in countries such as China and Japan. Serum 1,25-dihydroxyvitamin D3 level is inversely(More)
— The use of IP networks as common backbone is becoming of increased interest in today's building automation systems (BAS). With the use of IP also new attack scenarios that threaten the overall security of BAS are introduced. Due to the absence of native security mechanisms in IP and because of its long standing and pervasive use in the IT world, many(More)
— Extensive research has shown that most of road accidents occur as a result of driver errors. A close examination of accident data reveals that losing the vehicle control is responsible for a huge proportion of car accidents. Preventing such kind of accidents using vehicle control systems, requires certain input data concerning vehicle dynamic parameters(More)
— Knowledge of vehicle dynamic parameters is important for vehicle control systems that aim to enhance vehicle handling and passenger safety. Unfortunately, some fundamental parameters like tire-road forces and sideslip angle are difficult to measure in a car, for both technical and economic reasons. Therefore, this study presents a dynamic modeling and(More)